CHEMGRID MOLECULE CARD

Novel

Novel in ChemGrid: 5 screened assays, 1 with significant responses. Explore chemical identifiers, strain activity and target evidence.

LAT011F06

Explore activity & SONAR

Chemical structure of Novel — Stored molecular structure

5Screened assays

1Significant assay responses

6Source-labelled target records

Identity and chemistry

ChemGrid identifier: LAT011F06
Molecular formula: C12H16N2O2S
InChIKey: BHXXVDHXSBMVDI-UHFFFAOYSA-N
Libraries: LATCA
Other recorded names: N-[(2-methoxyphenyl)carbamothioyl]-2-methylpropanamide

Stored SMILES

COc1ccccc1NC(=S)NC(=O)C(C)C

Matched external records: PubChem 847561

Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.

Measured chemical–genetic activity

5 measurements across 5 distinct library–species–strain assays; 1 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).

Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.

Up to 12 strongest recorded single-strain responses by absolute Z-score
Strain	Library	Species identifier	Z-score
wt18h	LATCA	4932	-6.30

Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.

Recorded target evidence and yeast matches

Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.

Target	Source	Yeast ORF / orthologue
APEX1 · DNA repair nuclease/redox regulator APEX1	ChEMBL	No stored yeast mapping
EHMT2 · Histone-lysine N-methyltransferase EHMT2	ChEMBL	SET2 YJL168C (ortholog_many2many)
IDH1 · Isocitrate dehydrogenase [NADP] cytoplasmic	ChEMBL	IDP1 YDL066W (ortholog_many2many); IDP2 YLR174W (ortholog_many2many); IDP3 YNL009W (ortholog_many2many)
Rorc · Nuclear receptor ROR-gamma	ChEMBL	No stored yeast mapping
TGR · Thioredoxin glutathione reductase	ChEMBL	TRR1 YDR353W (ortholog_many2many); TRR2 YHR106W (ortholog_many2many)
Txnrd1 · Thioredoxin reductase 1, cytoplasmic	ChEMBL	TRR1 YDR353W (ortholog_many2many); TRR2 YHR106W (ortholog_many2many)

Structural activity predictions and SONAR

Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.

SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.

Open the complete Novel research profile →

Sources and provenance

Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.

Card snapshot: 2026-11-02. Linked interactive views may contain newer data.