CHEMGRID MOLECULE CARD
Novel
Novel in ChemGrid: 5 screened assays, 5 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LAT008H04
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LAT008H04
- Molecular formula
- C18ClH18NO3
- InChIKey
- NVNGUFUOKYOUJL-UHFFFAOYSA-N
- Libraries
- LATCA
- Other recorded names
- N-(3-chloro-1,4-dioxonaphthalen-2-yl)-N-cyclohexylacetamide
Stored SMILES
CC(=O)N(C1CCCCC1)c1c(Cl)c(=O)c2ccccc2c1=OMatched external records: PubChem 282594
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
5 measurements across 5 distinct library–species–strain assays; 5 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| wt24h | LATCA | 4932 | -42.41 |
| pdr24h | LATCA | 4932 | -40.13 |
| pdr22h | LATCA | 4932 | -36.83 |
| wt18h | LATCA | 4932 | -26.88 |
| pdr18h | LATCA | 4932 | -26.19 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| CACNA1B · Voltage-gated N-type calcium channel alpha-1B subunit/Amyloid beta A4 precursor protein-binding family A member 1 | ChEMBL | No stored yeast mapping |
| fba · Fructose-bisphosphate aldolase | ChEMBL | SMI1 YGR229C (ortholog_one2many) |
| ffp · 4'-phosphopantetheinyl transferase ffp | ChEMBL | No stored yeast mapping |
| HSP90AA1 · Heat shock protein HSP 90-alpha | ChEMBL | HSC82 YMR186W (ortholog_many2many); HSP82 YPL240C (ortholog_many2many) |
| KDM4E · Lysine-specific demethylase 4E | ChEMBL | YJR119C (ortholog_one2many) |
| PAX8 · Paired box protein Pax-8 | ChEMBL | No stored yeast mapping |
| PYK · Pyruvate kinase | ChEMBL | No stored yeast mapping |
| recA · Protein RecA | ChEMBL | RAD51 YER095W (ortholog_one2one) |
| S1PR4 · Sphingosine 1-phosphate receptor 4 | ChEMBL | No stored yeast mapping |
| SPHK1 · Sphingosine kinase 1 | ChEMBL | LCB5 YLR260W (ortholog_many2many); LCB4 YOR171C (ortholog_many2many) |
| TGR · Thioredoxin glutathione reductase | ChEMBL | TRR1 YDR353W (ortholog_many2many); TRR2 YHR106W (ortholog_many2many) |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete Novel research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.