CHEMGRID MOLECULE CARD
Amiloride
Amiloride in ChemGrid: 5 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LAT005D02
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LAT005D02
- Molecular formula
- C6ClH8N7O
- InChIKey
- XSDQTOBWRPYKKA-UHFFFAOYSA-N
- Libraries
- LATCA
Stored SMILES
NC(N)=NC(=O)c1nc(Cl)c(N)nc1NMatched external records: PubChem 16231
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
5 measurements across 5 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| ADRA1A · Alpha-1A adrenergic receptor | ChEMBL | No stored yeast mapping |
| EHMT2 · Histone-lysine N-methyltransferase EHMT2 | ChEMBL | SET2 YJL168C (ortholog_many2many) |
| LMNA · Prelamin-A/C | ChEMBL | No stored yeast mapping |
| PLAU · Urokinase-type plasminogen activator | ChEMBL | No stored yeast mapping |
| SCNN1A · Epithelial sodium channel subunit alpha | ChEMBL | No stored yeast mapping |
| Slc9a1 · Sodium/hydrogen exchanger 1 | ChEMBL | NHX1 YDR456W (ortholog_one2many) |
| SLC9A2 · Sodium/hydrogen exchanger 2 | ChEMBL | NHX1 YDR456W (ortholog_one2many) |
| SMPD1 · Sphingomyelin phosphodiesterase | ChEMBL | PPN1 YDR452W (ortholog_one2many) |
| Txnrd1 · Thioredoxin reductase 1, cytoplasmic | ChEMBL | TRR1 YDR353W (ortholog_many2many); TRR2 YHR106W (ortholog_many2many) |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete Amiloride research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.