CHEMGRID MOLECULE CARD
8-Quinolinol
8-Quinolinol in ChemGrid: 5 screened assays, 5 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LAT004B09
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LAT004B09
- Molecular formula
- C9H7NO
- InChIKey
- MCJGNVYPOGVAJF-UHFFFAOYSA-N
- Libraries
- LATCA
- Other recorded names
- 8-Hydroxyquinoline
Stored SMILES
Oc1cccc2cccnc12Matched external records: PubChem 1923
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
5 measurements across 5 distinct library–species–strain assays; 5 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| wt24h | LATCA | 4932 | -42.67 |
| pdr24h | LATCA | 4932 | -39.19 |
| pdr22h | LATCA | 4932 | -36.21 |
| wt18h | LATCA | 4932 | -26.93 |
| pdr18h | LATCA | 4932 | -25.76 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| Bacterial leucyl aminopeptidase | ChEMBL | No stored yeast mapping |
| BAZ2B · Bromodomain adjacent to zinc finger domain protein 2B | ChEMBL | BDF2 YDL070W (ortholog_many2many); BDF1 YLR399C (ortholog_many2many) |
| COMT · Catechol O-methyltransferase | ChEMBL | No stored yeast mapping |
| HSP90AA1 · Heat shock protein HSP90 | ChEMBL | HSC82 YMR186W (ortholog_many2many); HSP82 YPL240C (ortholog_many2many) |
| lef · Lethal factor | ChEMBL | No stored yeast mapping |
| METAP2 · Methionine aminopeptidase 2 | ChEMBL | No stored yeast mapping |
| Rorc · Nuclear receptor ROR-gamma | ChEMBL | No stored yeast mapping |
| Bacterial leucyl aminopeptidase | ChEMBL analogue | No stored yeast mapping |
| BAZ2B · Bromodomain adjacent to zinc finger domain protein 2B | ChEMBL analogue | BDF2 YDL070W (ortholog_many2many); BDF1 YLR399C (ortholog_many2many) |
| COMT · Catechol O-methyltransferase | ChEMBL analogue | No stored yeast mapping |
| HSP90AA1 · Heat shock protein HSP90 | ChEMBL analogue | HSC82 YMR186W (ortholog_many2many); HSP82 YPL240C (ortholog_many2many) |
| lef · Lethal factor | ChEMBL analogue | No stored yeast mapping |
| METAP2 · Methionine aminopeptidase 2 | ChEMBL analogue | No stored yeast mapping |
| Rorc · Nuclear receptor ROR-gamma | ChEMBL analogue | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete 8-Quinolinol research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.