CHEMGRID MOLECULE CARD
Tyrphostin AG 1478
Tyrphostin AG 1478 in ChemGrid: 5 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LAT004B07
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LAT004B07
- Molecular formula
- C16ClH14N3O2
- InChIKey
- GFNNBHLJANVSQV-UHFFFAOYSA-N
- Libraries
- LATCA
- Other recorded names
- N-(3-Chlorophenyl)-6,7-dimethoxy-4-quinazolinamine
Stored SMILES
COc1cc2ncnc(Nc3cccc(Cl)c3)c2cc1OCMatched external records: PubChem 2051
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
5 measurements across 5 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| ABL1 · Tyrosine-protein kinase ABL | ChEMBL | No stored yeast mapping |
| BLM · RecQ-like DNA helicase BLM | ChEMBL | SGS1 YMR190C (ortholog_one2one) |
| EGFR · Epidermal growth factor receptor | ChEMBL | No stored yeast mapping |
| FBP1 · Fructose-1,6-bisphosphatase 1 | ChEMBL | FBP1 YLR377C (ortholog_one2many) |
| GMNN · Geminin | ChEMBL | No stored yeast mapping |
| Impa1 · Inositol monophosphatase 1 | ChEMBL | No stored yeast mapping |
| MAPK1 · Mitogen-activated protein kinase 1 | ChEMBL | SLT2 YHR030C (ortholog_many2many); YKL161C (ortholog_many2many) |
| MAPK14 · Mitogen-activated protein kinase 14 | ChEMBL | SLT2 YHR030C (ortholog_many2many); YKL161C (ortholog_many2many) |
| MKNK1 · MAP kinase-interacting serine/threonine-protein kinase 1 | ChEMBL | No stored yeast mapping |
| PKMYT1 · Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase | ChEMBL | SWE1 YJL187C (ortholog_one2one) |
| ABL1 · Tyrosine-protein kinase ABL | ChEMBL analogue | No stored yeast mapping |
| BLM · RecQ-like DNA helicase BLM | ChEMBL analogue | SGS1 YMR190C (ortholog_one2one) |
| EGFR · Epidermal growth factor receptor | ChEMBL analogue | No stored yeast mapping |
| FBP1 · Fructose-1,6-bisphosphatase 1 | ChEMBL analogue | FBP1 YLR377C (ortholog_one2many) |
| GMNN · Geminin | ChEMBL analogue | No stored yeast mapping |
| Impa1 · Inositol monophosphatase 1 | ChEMBL analogue | No stored yeast mapping |
| MAPK1 · Mitogen-activated protein kinase 1 | ChEMBL analogue | SLT2 YHR030C (ortholog_many2many); YKL161C (ortholog_many2many) |
| MAPK14 · Mitogen-activated protein kinase 14 | ChEMBL analogue | SLT2 YHR030C (ortholog_many2many); YKL161C (ortholog_many2many) |
| MKNK1 · MAP kinase-interacting serine/threonine-protein kinase 1 | ChEMBL analogue | No stored yeast mapping |
| PKMYT1 · Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase | ChEMBL analogue | SWE1 YJL187C (ortholog_one2one) |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete Tyrphostin AG 1478 research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.