CHEMGRID MOLECULE CARD
Tetrac
Tetrac in ChemGrid: 5 screened assays, 2 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LAT002H11
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LAT002H11
- Molecular formula
- C14H8I4O4
- InChIKey
- PPJYSSNKSXAVDB-UHFFFAOYSA-N
- Libraries
- LATCA
- Other recorded names
- Tetraiodothyroacetic acid
Stored SMILES
OC(=O)Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1Matched external records: PubChem 65552
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
5 measurements across 5 distinct library–species–strain assays; 2 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| wt18h | LATCA | 4932 | -4.72 |
| pdr18h | LATCA | 4932 | -4.50 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| ITGB3 · Integrin alpha-V/beta-3 | ChEMBL | No stored yeast mapping |
| PPARG · Peroxisome proliferator-activated receptor gamma | ChEMBL | No stored yeast mapping |
| RXRA · Retinoic acid receptor RXR-alpha | ChEMBL | No stored yeast mapping |
| THRA · Thyroid hormone receptor alpha | ChEMBL | No stored yeast mapping |
| THRB · Thyroid hormone receptor beta | ChEMBL | No stored yeast mapping |
| ADRA1A · Alpha-1A adrenergic receptor | ChEMBL analogue | No stored yeast mapping |
| CYP2C9 · Cytochrome P450 2C9 | ChEMBL analogue | No stored yeast mapping |
| GABRA1 · Gamma-aminobutyric acid receptor subunit alpha-1/alpha-2/beta-2/gamma-2 | ChEMBL analogue | No stored yeast mapping |
| ITGB3 · Integrin alpha-V/beta-3 | ChEMBL analogue | No stored yeast mapping |
| KAT2A · Histone acetyltransferase KAT2A | ChEMBL analogue | BDF2 YDL070W (ortholog_many2many); BDF1 YLR399C (ortholog_many2many) |
| PDE4D · 3',5'-cyclic-AMP phosphodiesterase 4D | ChEMBL analogue | No stored yeast mapping |
| PPARG · Peroxisome proliferator-activated receptor gamma | ChEMBL analogue | No stored yeast mapping |
| RXRA · Retinoic acid receptor RXR-alpha | ChEMBL analogue | No stored yeast mapping |
| Slco1c1 · Solute carrier organic anion transporter family member 1C1 | ChEMBL analogue | No stored yeast mapping |
| THRA · Thyroid hormone receptor alpha | ChEMBL analogue | No stored yeast mapping |
| Thrb · Thyroid hormone receptor beta | ChEMBL analogue | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete Tetrac research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.