CHEMGRID MOLECULE CARD
Broxyquinoline
Broxyquinoline in ChemGrid: 5 screened assays, 5 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LAT002H08
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LAT002H08
- Molecular formula
- Br2C9H5NO
- InChIKey
- ZDASUJMDVPTNTF-UHFFFAOYSA-N
- Libraries
- LATCA
Stored SMILES
Oc1c(Br)cc(Br)c2cccnc12Matched external records: PubChem 2453
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
5 measurements across 5 distinct library–species–strain assays; 5 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| wt24h | LATCA | 4932 | -42.36 |
| pdr24h | LATCA | 4932 | -40.18 |
| pdr22h | LATCA | 4932 | -36.78 |
| wt18h | LATCA | 4932 | -26.69 |
| pdr18h | LATCA | 4932 | -26.10 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| HSP90 | ChEMBL | No stored yeast mapping |
| HSP90AA1 · Heat shock protein HSP 90-alpha | ChEMBL | HSC82 YMR186W (ortholog_many2many); HSP82 YPL240C (ortholog_many2many) |
| IDH1 · Isocitrate dehydrogenase [NADP] cytoplasmic | ChEMBL | IDP1 YDL066W (ortholog_many2many); IDP2 YLR174W (ortholog_many2many); IDP3 YNL009W (ortholog_many2many) |
| KDM4A · Lysine-specific demethylase 4A | ChEMBL | YJR119C (ortholog_one2many) |
| MEP2 · Ammonium transporter MEP2 | ChEMBL | No stored yeast mapping |
| Pmp22 · Peripheral myelin protein 22 | ChEMBL | No stored yeast mapping |
| Rorc · Nuclear receptor ROR-gamma | ChEMBL | No stored yeast mapping |
| TARDBP · TAR DNA-binding protein 43 | ChEMBL | PIN4 YBL051C (ortholog_many2many) |
| TDP1 · Tyrosyl-DNA phosphodiesterase 1 | ChEMBL | TDP1 YBR223C (ortholog_one2one) |
| USP2 · Ubiquitin carboxyl-terminal hydrolase 2 | ChEMBL | UBP13 YBL067C (ortholog_many2many); UBP9 YER098W (ortholog_many2many) |
| HSP90 | ChEMBL analogue | No stored yeast mapping |
| HSP90AA1 · Heat shock protein HSP 90-alpha | ChEMBL analogue | HSC82 YMR186W (ortholog_many2many); HSP82 YPL240C (ortholog_many2many) |
| IDH1 · Isocitrate dehydrogenase [NADP] cytoplasmic | ChEMBL analogue | IDP1 YDL066W (ortholog_many2many); IDP2 YLR174W (ortholog_many2many); IDP3 YNL009W (ortholog_many2many) |
| KDM4A · Lysine-specific demethylase 4A | ChEMBL analogue | YJR119C (ortholog_one2many) |
| MEP2 · Ammonium transporter MEP2 | ChEMBL analogue | No stored yeast mapping |
| Pmp22 · Peripheral myelin protein 22 | ChEMBL analogue | No stored yeast mapping |
| Rorc · Nuclear receptor ROR-gamma | ChEMBL analogue | No stored yeast mapping |
| TARDBP · TAR DNA-binding protein 43 | ChEMBL analogue | PIN4 YBL051C (ortholog_many2many) |
| TDP1 · Tyrosyl-DNA phosphodiesterase 1 | ChEMBL analogue | TDP1 YBR223C (ortholog_one2one) |
| USP2 · Ubiquitin carboxyl-terminal hydrolase 2 | ChEMBL analogue | UBP13 YBL067C (ortholog_many2many); UBP9 YER098W (ortholog_many2many) |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete Broxyquinoline research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.