CHEMGRID MOLECULE CARD
4-Methylesculetin
4-Methylesculetin in ChemGrid: 5 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LAT001D06
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LAT001D06
- Molecular formula
- C10H8O4
- InChIKey
- KVOJTUXGYQVLAJ-UHFFFAOYSA-N
- Libraries
- LATCA
Stored SMILES
CC1=CC(=O)Oc2cc(O)c(O)cc12Matched external records: PubChem 5319502
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
5 measurements across 5 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| Cruzipain | ChEMBL | No stored yeast mapping |
| AKR1B1 · Aldo-keto reductase family 1 member B1 | ChEMBL | AAD3 YCR107W (ortholog_many2many); AAD4 YDL243C (ortholog_many2many); YPR1 YDR368W (ortholog_many2many); AAD10 YJR155W (ortholog_many2many); AAD14 YNL331C (ortholog_many2many); AAD15 YOL165C (ortholog_many2many); GCY1 YOR120W (ortholog_many2many) |
| ALDH1A1 · Aldehyde dehydrogenase 1A1 | ChEMBL | ALD5 YER073W (ortholog_many2many); ALD3 YMR169C (ortholog_many2many); ALD2 YMR170C (ortholog_many2many); ALD4 YOR374W (ortholog_many2many); ALD6 YPL061W (ortholog_many2many) |
| HPGD · 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | ChEMBL | AYR1 YIL124W (ortholog_one2one) |
| HSD17B10 · 3-hydroxyacyl-CoA dehydrogenase type-2 | ChEMBL | No stored yeast mapping |
| KDM4E · Lysine-specific demethylase 4E | ChEMBL | YJR119C (ortholog_one2many) |
| MCL1 · Induced myeloid leukemia cell differentiation protein Mcl-1 | ChEMBL | No stored yeast mapping |
| MTOR · Serine/threonine-protein kinase mTOR | ChEMBL | No stored yeast mapping |
| SORD · Sorbitol dehydrogenase | ChEMBL | BDH1 YAL060W (ortholog_many2many); YAL061W (ortholog_many2many); YBL068W-A (ortholog_many2many); AST1 YBL069W (ortholog_many2many); YCR102C (ortholog_many2many); ADH7 YCR105W (ortholog_many2many); AST2 YER101C (ortholog_many2many); YLR460C (ortholog_many2many); ADH6 YMR318C (ortholog_many2many); YNL134C (ortholog_many2many) |
| THRB · Thyroid hormone receptor beta | ChEMBL | No stored yeast mapping |
| XDH · Xanthine dehydrogenase/oxidase | ChEMBL | No stored yeast mapping |
| Cruzipain | ChEMBL analogue | No stored yeast mapping |
| AKR1B1 · Aldo-keto reductase family 1 member B1 | ChEMBL analogue | AAD3 YCR107W (ortholog_many2many); AAD4 YDL243C (ortholog_many2many); YPR1 YDR368W (ortholog_many2many); AAD10 YJR155W (ortholog_many2many); AAD14 YNL331C (ortholog_many2many); AAD15 YOL165C (ortholog_many2many); GCY1 YOR120W (ortholog_many2many) |
| ALDH1A1 · Aldehyde dehydrogenase 1A1 | ChEMBL analogue | ALD5 YER073W (ortholog_many2many); ALD3 YMR169C (ortholog_many2many); ALD2 YMR170C (ortholog_many2many); ALD4 YOR374W (ortholog_many2many); ALD6 YPL061W (ortholog_many2many) |
| HPGD · 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | ChEMBL analogue | AYR1 YIL124W (ortholog_one2one) |
| HSD17B10 · 3-hydroxyacyl-CoA dehydrogenase type-2 | ChEMBL analogue | No stored yeast mapping |
| KDM4E · Lysine-specific demethylase 4E | ChEMBL analogue | YJR119C (ortholog_one2many) |
| MCL1 · Induced myeloid leukemia cell differentiation protein Mcl-1 | ChEMBL analogue | No stored yeast mapping |
| MTOR · Serine/threonine-protein kinase mTOR | ChEMBL analogue | No stored yeast mapping |
| SORD · Sorbitol dehydrogenase | ChEMBL analogue | BDH1 YAL060W (ortholog_many2many); YAL061W (ortholog_many2many); YBL068W-A (ortholog_many2many); AST1 YBL069W (ortholog_many2many); YCR102C (ortholog_many2many); ADH7 YCR105W (ortholog_many2many); AST2 YER101C (ortholog_many2many); YLR460C (ortholog_many2many); ADH6 YMR318C (ortholog_many2many); YNL134C (ortholog_many2many) |
| THRB · Thyroid hormone receptor beta | ChEMBL analogue | No stored yeast mapping |
| XDH · Xanthine dehydrogenase/oxidase | ChEMBL analogue | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete 4-Methylesculetin research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.