CHEMGRID MOLECULE CARD
Dihydrorotenone
Dihydrorotenone in ChemGrid: 5 screened assays, 1 with significant responses. Explore chemical identifiers, strain activity and target evidence.
LAT001C04
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- LAT001C04
- Molecular formula
- C23H24O6
- InChIKey
- DTFARBHXORYQBF-UHFFFAOYSA-N
- Libraries
- LATCA
- Other recorded names
- 16,17-Dimethoxy-6-propan-2-yl-2,7,20-trioxapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-3(11),4(8),9,14,16,18-hexaen-12-one
Stored SMILES
COc1cc2OCC3Oc4c5CC(Oc5ccc4C(=O)C3c2cc1OC)C(C)CMatched external records: PubChem 4323685
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
5 measurements across 5 distinct library–species–strain assays; 1 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| pdr18h | LATCA | 4932 | -11.30 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| Tegument protein VP16 | ChEMBL | No stored yeast mapping |
| CGA · Glycoprotein hormones alpha chain | ChEMBL | No stored yeast mapping |
| GALR3 · Galanin receptor type 3 | ChEMBL | No stored yeast mapping |
| GMNN · Geminin | ChEMBL | No stored yeast mapping |
| IDH1 · Isocitrate dehydrogenase [NADP] cytoplasmic | ChEMBL | IDP1 YDL066W (ortholog_many2many); IDP2 YLR174W (ortholog_many2many); IDP3 YNL009W (ortholog_many2many) |
| KDM4A · Lysine-specific demethylase 4A | ChEMBL | YJR119C (ortholog_one2many) |
| NFE2L2 · Nuclear factor erythroid 2-related factor 2 | ChEMBL | No stored yeast mapping |
| NR2F2 · COUP transcription factor 2 | ChEMBL | No stored yeast mapping |
| POLI · DNA polymerase iota | ChEMBL | No stored yeast mapping |
| RAPGEF4 · Rap guanine nucleotide exchange factor 4 | ChEMBL | LTE1 YAL024C (ortholog_many2many) |
| SMAD3 · Mothers against decapentaplegic homolog 3 | ChEMBL | No stored yeast mapping |
| TDP1 · Tyrosyl-DNA phosphodiesterase 1 | ChEMBL | TDP1 YBR223C (ortholog_one2one) |
| Tegument protein VP16 | ChEMBL analogue | No stored yeast mapping |
| CGA · Glycoprotein hormones alpha chain | ChEMBL analogue | No stored yeast mapping |
| GALR3 · Galanin receptor type 3 | ChEMBL analogue | No stored yeast mapping |
| GMNN · Geminin | ChEMBL analogue | No stored yeast mapping |
| IDH1 · Isocitrate dehydrogenase [NADP] cytoplasmic | ChEMBL analogue | IDP1 YDL066W (ortholog_many2many); IDP2 YLR174W (ortholog_many2many); IDP3 YNL009W (ortholog_many2many) |
| KDM4A · Lysine-specific demethylase 4A | ChEMBL analogue | YJR119C (ortholog_one2many) |
| NFE2L2 · Nuclear factor erythroid 2-related factor 2 | ChEMBL analogue | No stored yeast mapping |
| NR2F2 · COUP transcription factor 2 | ChEMBL analogue | No stored yeast mapping |
| POLI · DNA polymerase iota | ChEMBL analogue | No stored yeast mapping |
| RAPGEF4 · Rap guanine nucleotide exchange factor 4 | ChEMBL analogue | LTE1 YAL024C (ortholog_many2many) |
| SMAD3 · Mothers against decapentaplegic homolog 3 | ChEMBL analogue | No stored yeast mapping |
| TDP1 · Tyrosyl-DNA phosphodiesterase 1 | ChEMBL analogue | TDP1 YBR223C (ortholog_one2one) |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete Dihydrorotenone research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.