CHEMGRID MOLECULE CARD

7-chloro-N-(2-fluoro-4-iodophenyl)quinolin-4-amine

7-chloro-N-(2-fluoro-4-iodophenyl)quinolin-4-amine in ChemGrid: 71 screened assays, 2 with significant responses. Explore chemical identifiers, strain activity and target evidence.

KM 11072

Explore activity & SONAR

Chemical structure of 7-chloro-N-(2-fluoro-4-iodophenyl)quinolin-4-amine — Stored molecular structure

71Screened assays

2Significant assay responses

4Source-labelled target records

Identity and chemistry

ChemGrid identifier: KM 11072
Molecular formula: C15ClFH9IN2
InChIKey: SGYXYQQGWNUEIG-UHFFFAOYSA-N
Libraries: Maybridge, Bioactive

Stored SMILES

Fc1cc(I)ccc1Nc1ccnc2cc(Cl)ccc12

Matched external records: PubChem 2823698

Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.

Measured chemical–genetic activity

71 measurements across 71 distinct library–species–strain assays; 2 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).

Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.

Up to 12 strongest recorded single-strain responses by absolute Z-score
Strain	Library	Species identifier	Z-score
pdryCG200	Bioactive	4932	-7.94
SLT2	Bioactive	4932	-4.28

Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.

Recorded target evidence and yeast matches

Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.

Target	Source	Yeast ORF / orthologue
Dihydroorotate dehydrogenase, mitochondrial, putative	ChEMBL	No stored yeast mapping
dhod · Dihydroorotate dehydrogenase	ChEMBL	No stored yeast mapping
DHODH · Dihydroorotate dehydrogenase (quinone), mitochondrial	ChEMBL	No stored yeast mapping
URA1 · Dihydroorotate dehydrogenase (fumarate)	ChEMBL	YKL216W (source annotation)

Structural activity predictions and SONAR

Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.

SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.

Open the complete 7-chloro-N-(2-fluoro-4-iodophenyl)quinolin-4-amine research profile →

Sources and provenance

Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.

Card snapshot: 2026-11-02. Linked interactive views may contain newer data.