CHEMGRID MOLECULE CARD
ethyl 2-(5-cyano-3-isopropyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-1-yl)acetate
ethyl 2-(5-cyano-3-isopropyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-1-yl)acetate in ChemGrid: 50 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
KM 07867
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- KM 07867
- Molecular formula
- C12H15N3O4
- InChIKey
- KMGGZXYSRIQEQT-UHFFFAOYSA-N
- Libraries
- Maybridge1000
- Other recorded names
- Ethyl 2-(5-cyano-3-isopropyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-1-yl)acetate
Stored SMILES
CCOC(=O)CN1C(=O)N(C=C(C#N)C1=O)C(C)CMatched external records: PubChem 2822043
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
50 measurements across 50 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| ATXN2 · Ataxin-2 | ChEMBL | No stored yeast mapping |
| CBX1 · Chromobox protein homolog 1 | ChEMBL | No stored yeast mapping |
| GMNN · Geminin | ChEMBL | No stored yeast mapping |
| KDM4E · Lysine-specific demethylase 4E | ChEMBL | YJR119C (ortholog_one2many) |
| POLB · DNA polymerase beta | ChEMBL | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete ethyl 2-(5-cyano-3-isopropyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-1-yl)acetate research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.