CHEMGRID MOLECULE CARD
N-[(2H-1,3-Benzodioxol-5-YL)methyl]-6-[(2,5-dimethylphenyl)methyl]-5,7-dimethylpyrazolo[1,5-A]pyrimidine-3-carboxamide
N-[(2H-1,3-Benzodioxol-5-YL)methyl]-6-[(2,5-dimethylphenyl)methyl]-5,7-dimethylpyrazolo[1,5-A]pyrimidine-3-carboxamide in ChemGrid: 3 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
K784-3469
Explore activity & SONAR![Chemical structure of N-[(2H-1,3-Benzodioxol-5-YL)methyl]-6-[(2,5-dimethylphenyl)methyl]-5,7-dimethylpyrazolo[1,5-A]pyrimidine-3-carboxamide](/structure-thumbnails/ChemDiv-Kinase/K7/K784-3469.svg?v=2026-09-22T13%3A54%3A31%2B00%3A00)
Identity and chemistry
- ChemGrid identifier
- K784-3469
- Molecular formula
- C26H26N4O3
- InChIKey
- GTDQOSKTSLCIDZ-UHFFFAOYSA-N
- Libraries
- ChemDiv-Kinase
Stored SMILES
Cc1ccc(C)c(CC2C(C)=Nc3n(ncc3C(=O)NCc3ccc4OCOc4c3)C=2C)c1Matched external records: PubChem 5069258
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
3 measurements across 3 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| ALDH1A1 · Aldehyde dehydrogenase 1A1 | ChEMBL | ALD5 YER073W (ortholog_many2many); ALD3 YMR169C (ortholog_many2many); ALD2 YMR170C (ortholog_many2many); ALD4 YOR374W (ortholog_many2many); ALD6 YPL061W (ortholog_many2many) |
| ampC · Beta-lactamase | ChEMBL | No stored yeast mapping |
| ATAD5 · ATPase family AAA domain-containing protein 5 | ChEMBL | No stored yeast mapping |
| ffp · 4'-phosphopantetheinyl transferase ffp | ChEMBL | No stored yeast mapping |
| FTL · Ferritin light chain | ChEMBL | No stored yeast mapping |
| GBA1 · Lysosomal acid glucosylceramidase | ChEMBL | No stored yeast mapping |
| HPGD · 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | ChEMBL | AYR1 YIL124W (ortholog_one2one) |
| Impa1 · Inositol monophosphatase 1 | ChEMBL | No stored yeast mapping |
| KDM4E · Lysine-specific demethylase 4E | ChEMBL | YJR119C (ortholog_one2many) |
| MAPT · Microtubule-associated protein tau | ChEMBL | No stored yeast mapping |
| NPSR1 · Neuropeptide S receptor | ChEMBL | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete N-[(2H-1,3-Benzodioxol-5-YL)methyl]-6-[(2,5-dimethylphenyl)methyl]-5,7-dimethylpyrazolo[1,5-A]pyrimidine-3-carboxamide research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.