CHEMGRID MOLECULE CARD
1-(4-chlorophenyl)-4-[4-(2-fluorophenyl)piperazin-1-yl]-1H-pyrazolo[3,4-d]pyrimidine
1-(4-chlorophenyl)-4-[4-(2-fluorophenyl)piperazin-1-yl]-1H-pyrazolo[3,4-d]pyrimidine in ChemGrid: 3 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
K402-0682
Explore activity & SONAR![Chemical structure of 1-(4-chlorophenyl)-4-[4-(2-fluorophenyl)piperazin-1-yl]-1H-pyrazolo[3,4-d]pyrimidine](/structure-thumbnails/ChemDiv-Kinase/K4/K402-0682.svg?v=2026-09-22T13%3A54%3A31%2B00%3A00)
Identity and chemistry
- ChemGrid identifier
- K402-0682
- Molecular formula
- C21ClFH18N6
- InChIKey
- VQUAFVNBLPVXIK-UHFFFAOYSA-N
- Libraries
- ChemDiv-Kinase
Stored SMILES
Fc1ccccc1N1CCN(CC1)c1ncnc2n(ncc12)c1ccc(Cl)cc1Matched external records: PubChem 1277956
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
3 measurements across 3 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| SLC2A1 · Solute carrier family 2, facilitated glucose transporter member 1 | ChEMBL analogue | YBR241C (ortholog_many2many); MAL31 YBR298C (ortholog_many2many); RGT2 YDL138W (ortholog_many2many); SNF3 YDL194W (ortholog_many2many); HXT15 YDL245C (ortholog_many2many); MPH2 YDL247W (ortholog_many2many); HXT7 YDR342C (ortholog_many2many); HXT6 YDR343C (ortholog_many2many); HXT3 YDR345C (ortholog_many2many); HXT13 YEL069C (ortholog_many2many); HXT10 YFL011W (ortholog_many2many); VPS73 YGL104C (ortholog_many2many); MAL11 YGR289C (ortholog_many2many); HXT4 YHR092C (ortholog_many2many); HXT1 YHR094C (ortholog_many2many); HXT5 YHR096C (ortholog_many2many); HXT8 YJL214W (ortholog_many2many); HXT9 YJL219W (ortholog_many2many); HXT16 YJR158W (ortholog_many2many); MPH3 YJR160C (ortholog_many2many); GAL2 YLR081W (ortholog_many2many); HXT2 YMR011W (ortholog_many2many); HXT17 YNR072W (ortholog_many2many); HXT11 YOL156W (ortholog_many2many) |
| SLC2A2 · Solute carrier family 2, facilitated glucose transporter member 2 | ChEMBL analogue | YBR241C (ortholog_many2many); MAL31 YBR298C (ortholog_many2many); RGT2 YDL138W (ortholog_many2many); SNF3 YDL194W (ortholog_many2many); HXT15 YDL245C (ortholog_many2many); MPH2 YDL247W (ortholog_many2many); HXT7 YDR342C (ortholog_many2many); HXT6 YDR343C (ortholog_many2many); HXT3 YDR345C (ortholog_many2many); HXT13 YEL069C (ortholog_many2many); HXT10 YFL011W (ortholog_many2many); VPS73 YGL104C (ortholog_many2many); MAL11 YGR289C (ortholog_many2many); HXT4 YHR092C (ortholog_many2many); HXT1 YHR094C (ortholog_many2many); HXT5 YHR096C (ortholog_many2many); HXT8 YJL214W (ortholog_many2many); HXT9 YJL219W (ortholog_many2many); HXT16 YJR158W (ortholog_many2many); MPH3 YJR160C (ortholog_many2many); GAL2 YLR081W (ortholog_many2many); HXT2 YMR011W (ortholog_many2many); HXT17 YNR072W (ortholog_many2many); HXT11 YOL156W (ortholog_many2many) |
| SLC2A3 · Solute carrier family 2, facilitated glucose transporter member 3 | ChEMBL analogue | YBR241C (ortholog_many2many); MAL31 YBR298C (ortholog_many2many); RGT2 YDL138W (ortholog_many2many); SNF3 YDL194W (ortholog_many2many); HXT15 YDL245C (ortholog_many2many); MPH2 YDL247W (ortholog_many2many); HXT7 YDR342C (ortholog_many2many); HXT6 YDR343C (ortholog_many2many); HXT3 YDR345C (ortholog_many2many); HXT13 YEL069C (ortholog_many2many); HXT10 YFL011W (ortholog_many2many); VPS73 YGL104C (ortholog_many2many); MAL11 YGR289C (ortholog_many2many); HXT4 YHR092C (ortholog_many2many); HXT1 YHR094C (ortholog_many2many); HXT5 YHR096C (ortholog_many2many); HXT8 YJL214W (ortholog_many2many); HXT9 YJL219W (ortholog_many2many); HXT16 YJR158W (ortholog_many2many); MPH3 YJR160C (ortholog_many2many); GAL2 YLR081W (ortholog_many2many); HXT2 YMR011W (ortholog_many2many); HXT17 YNR072W (ortholog_many2many); HXT11 YOL156W (ortholog_many2many) |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete 1-(4-chlorophenyl)-4-[4-(2-fluorophenyl)piperazin-1-yl]-1H-pyrazolo[3,4-d]pyrimidine research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.