CHEMGRID MOLECULE CARD
5-[(4-oxo-2-phenyl-4H-chromen-7-yl)oxy]pentanenitrile
5-[(4-oxo-2-phenyl-4H-chromen-7-yl)oxy]pentanenitrile in ChemGrid: 71 screened assays, 4 with significant responses. Explore chemical identifiers, strain activity and target evidence.
JFD 00150
Explore activity & SONAR![Chemical structure of 5-[(4-oxo-2-phenyl-4H-chromen-7-yl)oxy]pentanenitrile](/structure-thumbnails/Maybridge/JF/JFD_00150.svg?v=2026-09-22T13%3A54%3A31%2B00%3A00)
Identity and chemistry
- ChemGrid identifier
- JFD 00150
- Molecular formula
- C20H17NO3
- InChIKey
- RMBWWDVYAYUVTR-UHFFFAOYSA-N
- Libraries
- Maybridge, Bioactive
- Other recorded names
- 5-(4-Oxo-2-phenylchromen-7-yl)oxypentanenitrile
Stored SMILES
O=C1C=C(Oc2cc(OCCCCC#N)ccc12)c1ccccc1Matched external records: PubChem 2817216
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
71 measurements across 71 distinct library–species–strain assays; 4 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| pdryCG200 | Bioactive | 4932 | -33.80 |
| pdryCG196log | Bioactive | 4932 | -21.91 |
| pdryCG196 | Bioactive | 4932 | -21.42 |
| CLN2 | Bioactive | 4932 | 4.23 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| TNKS · Poly [ADP-ribose] polymerase tankyrase-1 | ChEMBL | No stored yeast mapping |
| Luciferin 4-monooxygenase | ChEMBL analogue | No stored yeast mapping |
| LMNA · Prelamin-A/C | ChEMBL analogue | No stored yeast mapping |
| MAPT · Microtubule-associated protein tau | ChEMBL analogue | No stored yeast mapping |
| MEN1 · Menin/Histone-lysine N-methyltransferase MLL | ChEMBL analogue | No stored yeast mapping |
| Pmp22 · Peripheral myelin protein 22 | ChEMBL analogue | No stored yeast mapping |
| Rorc · Nuclear receptor ROR-gamma | ChEMBL analogue | No stored yeast mapping |
| SAMHD1 · Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | ChEMBL analogue | No stored yeast mapping |
| SMN1 · Survival motor neuron protein | ChEMBL analogue | No stored yeast mapping |
| TP53 · Cellular tumor antigen p53 | ChEMBL analogue | No stored yeast mapping |
| USP1 · Ubiquitin carboxyl-terminal hydrolase 1 | ChEMBL analogue | UBP13 YBL067C (ortholog_many2many); UBP9 YER098W (ortholog_many2many); UBP8 YMR223W (ortholog_many2many); UBP2 YOR124C (ortholog_many2many) |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete 5-[(4-oxo-2-phenyl-4H-chromen-7-yl)oxy]pentanenitrile research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.