CHEMGRID MOLECULE CARD
N-(3-chlorophenyl)-6,7-dimethoxyquinazolin-4-amine
N-(3-chlorophenyl)-6,7-dimethoxyquinazolin-4-amine in ChemGrid: 50 screened assays, 23 with significant responses. Explore chemical identifiers, strain activity and target evidence.
GK 03499
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- GK 03499
- Molecular formula
- C16ClH14N3O2
- InChIKey
- GFNNBHLJANVSQV-UHFFFAOYSA-N
- Libraries
- Maybridge1000
- Other recorded names
- N-(3-Chlorophenyl)-6,7-dimethoxy-4-quinazolinamine
Stored SMILES
COc1cc2ncnc(Nc3cccc(Cl)c3)c2cc1OCMatched external records: PubChem 2051
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
50 measurements across 50 distinct library–species–strain assays; 23 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| But24 | Maybridge1000 | 4932 | -26.22 |
| CHRA24 | Maybridge1000 | 4932 | -19.70 |
| MT2481-Camptothecin | Maybridge1000 | 4932 | -17.71 |
| MT2481-Fenbendazole | Maybridge1000 | 4932 | -14.40 |
| MT2481-pdr1pdr3 | Maybridge1000 | 4932 | -11.53 |
| arp6 | Maybridge1000 | 4932 | -9.79 |
| Peu18 | Maybridge1000 | 4932 | -9.66 |
| cin8 | Maybridge1000 | 4932 | -7.29 |
| MT2481-Cantharidin | Maybridge1000 | 4932 | -6.47 |
| But18 | Maybridge1000 | 4932 | -6.42 |
| PPH21 | Maybridge1000 | 4932 | -6.38 |
| cin2 | Maybridge1000 | 4932 | -6.37 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| ABL1 · Tyrosine-protein kinase ABL | ChEMBL | No stored yeast mapping |
| BLM · RecQ-like DNA helicase BLM | ChEMBL | SGS1 YMR190C (ortholog_one2one) |
| EGFR · Epidermal growth factor receptor | ChEMBL | No stored yeast mapping |
| FBP1 · Fructose-1,6-bisphosphatase 1 | ChEMBL | FBP1 YLR377C (ortholog_one2many) |
| GMNN · Geminin | ChEMBL | No stored yeast mapping |
| Impa1 · Inositol monophosphatase 1 | ChEMBL | No stored yeast mapping |
| MAPK1 · Mitogen-activated protein kinase 1 | ChEMBL | SLT2 YHR030C (ortholog_many2many); YKL161C (ortholog_many2many) |
| MAPK14 · Mitogen-activated protein kinase 14 | ChEMBL | SLT2 YHR030C (ortholog_many2many); YKL161C (ortholog_many2many) |
| MKNK1 · MAP kinase-interacting serine/threonine-protein kinase 1 | ChEMBL | No stored yeast mapping |
| PKMYT1 · Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase | ChEMBL | SWE1 YJL187C (ortholog_one2one) |
| ABL1 · Tyrosine-protein kinase ABL | ChEMBL analogue | No stored yeast mapping |
| BLM · RecQ-like DNA helicase BLM | ChEMBL analogue | SGS1 YMR190C (ortholog_one2one) |
| EGFR · Epidermal growth factor receptor | ChEMBL analogue | No stored yeast mapping |
| FBP1 · Fructose-1,6-bisphosphatase 1 | ChEMBL analogue | FBP1 YLR377C (ortholog_one2many) |
| GMNN · Geminin | ChEMBL analogue | No stored yeast mapping |
| Impa1 · Inositol monophosphatase 1 | ChEMBL analogue | No stored yeast mapping |
| MAPK1 · Mitogen-activated protein kinase 1 | ChEMBL analogue | SLT2 YHR030C (ortholog_many2many); YKL161C (ortholog_many2many) |
| MAPK14 · Mitogen-activated protein kinase 14 | ChEMBL analogue | SLT2 YHR030C (ortholog_many2many); YKL161C (ortholog_many2many) |
| MKNK1 · MAP kinase-interacting serine/threonine-protein kinase 1 | ChEMBL analogue | No stored yeast mapping |
| PKMYT1 · Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase | ChEMBL analogue | SWE1 YJL187C (ortholog_one2one) |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete N-(3-chlorophenyl)-6,7-dimethoxyquinazolin-4-amine research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.