CHEMGRID MOLECULE CARD
1,4-dihydrothieno[3,2-d]pyrimidin-4-one
1,4-dihydrothieno[3,2-d]pyrimidin-4-one in ChemGrid: 50 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
GK 00357
Explore activity & SONAR![Chemical structure of 1,4-dihydrothieno[3,2-d]pyrimidin-4-one](/structure-thumbnails/Maybridge1000/GK/GK_00357.svg?v=2026-09-22T13%3A54%3A31%2B00%3A00)
Identity and chemistry
- ChemGrid identifier
- GK 00357
- Molecular formula
- C6H4N2OS
- InChIKey
- PZMKGWRBZNOIPQ-UHFFFAOYSA-N
- Libraries
- Maybridge1000
- Other recorded names
- 3H,4H-thieno[3,2-d]pyrimidin-4-one
Stored SMILES
O=C1N=CNc2ccsc21Matched external records: PubChem 135417422
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
50 measurements across 50 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| CBX1 · Chromobox protein homolog 1 | ChEMBL | No stored yeast mapping |
| HSPA5 · Endoplasmic reticulum chaperone BiP | ChEMBL | No stored yeast mapping |
| PARP1 · Poly [ADP-ribose] polymerase 1 | ChEMBL | No stored yeast mapping |
| PDPK1 · 3-phosphoinositide-dependent protein kinase 1 | ChEMBL | PKH1 YDR490C (ortholog_one2many); PKH2 YOL100W (ortholog_one2many) |
| POLI · DNA polymerase iota | ChEMBL | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete 1,4-dihydrothieno[3,2-d]pyrimidin-4-one research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.