CHEMGRID MOLECULE CARD
9b-phenyl-2,3,5,9b-tetrahydro-1H-imidazo[2,1-a]isoindol-5-one
9b-phenyl-2,3,5,9b-tetrahydro-1H-imidazo[2,1-a]isoindol-5-one in ChemGrid: 50 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
DSHS 01050
Explore activity & SONAR![Chemical structure of 9b-phenyl-2,3,5,9b-tetrahydro-1H-imidazo[2,1-a]isoindol-5-one](/structure-thumbnails/Maybridge1000/DS/DSHS_01050.svg?v=2026-09-22T13%3A54%3A31%2B00%3A00)
Identity and chemistry
- ChemGrid identifier
- DSHS 01050
- Molecular formula
- C16H14N2O
- InChIKey
- VHOLDVWNAVAZQQ-UHFFFAOYSA-N
- Libraries
- Maybridge1000
- Other recorded names
- 9b-phenyl-1,2,3,9b-tetrahydro-5H-imidazo[2,1-a]isoindol-5-one
Stored SMILES
O=C1N2CCNC2(c2ccccc2)c2ccccc12Matched external records: PubChem 455107
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
50 measurements across 50 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| GNAS · Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | ChEMBL | GPA2 YER020W (ortholog_many2many); GPA1 YHR005C (ortholog_many2many) |
| NPC1 · NPC intracellular cholesterol transporter 1 | ChEMBL | NCR1 YPL006W (ortholog_one2one) |
| pol · Human immunodeficiency virus type 1 reverse transcriptase | ChEMBL | No stored yeast mapping |
| POLB · DNA polymerase beta | ChEMBL | No stored yeast mapping |
| SAMHD1 · Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | ChEMBL | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete 9b-phenyl-2,3,5,9b-tetrahydro-1H-imidazo[2,1-a]isoindol-5-one research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.