CHEMGRID MOLECULE CARD
2-(2-chlorophenyl)-1,2,3,4-tetrahydroquinazolin-4-one
2-(2-chlorophenyl)-1,2,3,4-tetrahydroquinazolin-4-one in ChemGrid: 50 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
DSHS 00663
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- DSHS 00663
- Molecular formula
- C14ClH11N2O
- InChIKey
- YTAHHRUYKJSTCG-UHFFFAOYSA-N
- Libraries
- Maybridge1000
- Other recorded names
- Mls002702065
Stored SMILES
Clc1ccccc1C1NC(=O)c2ccccc2N1Matched external records: PubChem 300570
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
50 measurements across 50 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| RAN · GTP-binding nuclear protein Ran/Importin subunit beta-1/Snurportin-1 | ChEMBL | GSP1 YLR293C (ortholog_one2many); GSP2 YOR185C (ortholog_one2many) |
| Txnrd1 · Thioredoxin reductase 1, cytoplasmic | ChEMBL | TRR1 YDR353W (ortholog_many2many); TRR2 YHR106W (ortholog_many2many) |
| PBRM1 · Protein polybromo-1 | ChEMBL analogue | No stored yeast mapping |
| SMARCA2 · SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 | ChEMBL analogue | No stored yeast mapping |
| SMARCA4 · SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4 | ChEMBL analogue | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete 2-(2-chlorophenyl)-1,2,3,4-tetrahydroquinazolin-4-one research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.