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CHEMGRID MOLECULE CARD

2-phenyl-1,2,4-triazaspiro[4.5]dec-3-ene-3-thiol

2-phenyl-1,2,4-triazaspiro[4.5]dec-3-ene-3-thiol in ChemGrid: 50 screened assays, 40 with significant responses. Explore chemical identifiers, strain activity and target evidence.

CD 03187

Explore activity & SONAR
Chemical structure of 2-phenyl-1,2,4-triazaspiro[4.5]dec-3-ene-3-thiol
Stored molecular structure
50Screened assays
40Significant assay responses
12Source-labelled target records

Identity and chemistry

ChemGrid identifier
CD 03187
Molecular formula
C13H17N3S
InChIKey
MUADWFSXXPVRAV-UHFFFAOYSA-N
Libraries
Maybridge1000
Other recorded names
2-Phenyl-1,2,4-triazaspiro[4.5]dec-3-ene-3-thiol
Stored SMILESSC1=NC2(CCCCC2)NN1c1ccccc1

Matched external records: PubChem 749973

Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.

Measured chemical–genetic activity

50 measurements across 50 distinct library–species–strain assays; 40 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).

Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.

Up to 12 strongest recorded single-strain responses by absolute Z-score
StrainLibrarySpecies identifierZ-score
Smi1Maybridge10004932-54.40
CNB1Maybridge10004932-53.64
MT2481-CantharidinMaybridge10004932-52.34
WT-CAMPMaybridge10004932-50.13
MT2481-cyclosporineMaybridge10004932-48.22
WT-CiclosporinMaybridge10004932-45.95
PPH21Maybridge10004932-45.87
WT-FenMaybridge10004932-42.82
BY4741Maybridge10004932-42.66
TEP1Maybridge10004932-40.88
cin2Maybridge10004932-38.64
cin8Maybridge10004932-37.67

Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.

Recorded target evidence and yeast matches

Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.

TargetSourceYeast ORF / orthologue
ampC · Beta-lactamaseChEMBLNo stored yeast mapping
BAZ2B · Bromodomain adjacent to zinc finger domain protein 2BChEMBLBDF2 YDL070W (ortholog_many2many); BDF1 YLR399C (ortholog_many2many)
CBX1 · Chromobox protein homolog 1ChEMBLNo stored yeast mapping
EHMT2 · Histone-lysine N-methyltransferase EHMT2ChEMBLSET2 YJL168C (ortholog_many2many)
GAA · Lysosomal alpha-glucosidaseChEMBLROT2 YBR229C (ortholog_one2many)
GFER · FAD-linked sulfhydryl oxidase ALRChEMBLERV1 YGR029W (ortholog_one2one)
KAT2A · Histone acetyltransferase KAT2AChEMBLBDF2 YDL070W (ortholog_many2many); BDF1 YLR399C (ortholog_many2many)
MAPT · Microtubule-associated protein tauChEMBLNo stored yeast mapping
POLI · DNA polymerase iotaChEMBLNo stored yeast mapping
Rorc · Nuclear receptor ROR-gammaChEMBLNo stored yeast mapping
TDP1 · Tyrosyl-DNA phosphodiesterase 1ChEMBLTDP1 YBR223C (ortholog_one2one)
vpr · Aberrant vpr proteinChEMBLNo stored yeast mapping

Structural activity predictions and SONAR

Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.

SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.

Open the complete 2-phenyl-1,2,4-triazaspiro[4.5]dec-3-ene-3-thiol research profile →

Sources and provenance

Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.

Card snapshot: 2026-11-02. Linked interactive views may contain newer data.