CHEMGRID MOLECULE CARD
3-(1H-indol-3-ylmethylidene)indolin-2-one
3-(1H-indol-3-ylmethylidene)indolin-2-one in ChemGrid: 71 screened assays, 51 with significant responses. Explore chemical identifiers, strain activity and target evidence.
CD 00823
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- CD 00823
- Molecular formula
- C17H12N2O
- InChIKey
- XCGXAWJRNVHWAI-UHFFFAOYSA-N
- Libraries
- Maybridge, Bioactive
- Other recorded names
- 3-((1H-indol-3-yl)methylene)indolin-2-one
Stored SMILES
O=c1nc2ccccc2c1=Cc1cnc2ccccc21Matched external records: PubChem 315880
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
71 measurements across 71 distinct library–species–strain assays; 51 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| pdryCG196log | Bioactive | 4932 | -41.06 |
| pdryCG200 | Bioactive | 4932 | -40.85 |
| pdryCG196 | Bioactive | 4932 | -34.96 |
| LST8 | Bioactive | 4932 | -28.83 |
| DUN1 | Bioactive | 4932 | -27.65 |
| HOG1 | Bioactive | 4932 | -25.84 |
| CLN2 | Bioactive | 4932 | -24.73 |
| SLT2 | Bioactive | 4932 | -24.18 |
| BY4741-3rd | Bioactive | 4932 | -24.04 |
| TSCII | Bioactive | 4932 | -23.83 |
| cdc34 | Bioactive | 4932 | -22.78 |
| CDC15 | Bioactive | 4932 | -22.59 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| AURKB · Aurora kinase B | ChEMBL | IPL1 YPL209C (ortholog_one2many) |
| CSF1R · Macrophage colony-stimulating factor 1 receptor | ChEMBL | No stored yeast mapping |
| CSNK1A1 · Casein kinase I isoform alpha | ChEMBL | YCK3 YER123W (ortholog_many2many); YCK1 YHR135C (ortholog_many2many); YCK2 YNL154C (ortholog_many2many) |
| FLT3 · Receptor-type tyrosine-protein kinase FLT3 | ChEMBL | No stored yeast mapping |
| KDR · Vascular endothelial growth factor receptor 2 | ChEMBL | No stored yeast mapping |
| LRRK2 · Leucine-rich repeat serine/threonine-protein kinase 2 | ChEMBL | No stored yeast mapping |
| LTK · Leukocyte tyrosine kinase receptor | ChEMBL | No stored yeast mapping |
| MAP4K2 · Mitogen-activated protein kinase kinase kinase kinase 2 | ChEMBL | CDC15 YAR019C (ortholog_many2many); SSK22 YCR073C (ortholog_many2many); SPS1 YDR523C (ortholog_many2many); STE20 YHL007C (ortholog_many2many); BCK1 YJL095W (ortholog_many2many); CLA4 YNL298W (ortholog_many2many); SSK2 YNR031C (ortholog_many2many); SKM1 YOL113W (ortholog_many2many) |
| NTRK2 · BDNF/NT-3 growth factors receptor | ChEMBL | No stored yeast mapping |
| NTRK3 · NT-3 growth factor receptor | ChEMBL | No stored yeast mapping |
| PDGFRB · Platelet-derived growth factor receptor beta | ChEMBL | No stored yeast mapping |
| RET · Proto-oncogene tyrosine-protein kinase receptor Ret | ChEMBL | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete 3-(1H-indol-3-ylmethylidene)indolin-2-one research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.