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CHEMGRID MOLECULE CARD

1-(4-chlorophenyl)-5-(2,3-dihydro-1,4-benzodioxin-6-yl)-6-ethyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one

1-(4-chlorophenyl)-5-(2,3-dihydro-1,4-benzodioxin-6-yl)-6-ethyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one in ChemGrid: 3 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.

C374-1658

Explore activity & SONAR
Chemical structure of 1-(4-chlorophenyl)-5-(2,3-dihydro-1,4-benzodioxin-6-yl)-6-ethyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one
Stored molecular structure
3Screened assays
0Significant assay responses
4Source-labelled target records

Identity and chemistry

ChemGrid identifier
C374-1658
Molecular formula
C21ClH17N4O3
InChIKey
SUMPQDKNNCLXKZ-UHFFFAOYSA-N
Libraries
ChemDiv-Kinase
Stored SMILESCCC1=Nc2n(ncc2C(=O)N1c1ccc2OCCOc2c1)c1ccc(Cl)cc1

Matched external records: PubChem 3236186

Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.

Measured chemical–genetic activity

3 measurements across 3 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).

Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.

Recorded target evidence and yeast matches

Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.

TargetSourceYeast ORF / orthologue
ATXN2 · Ataxin-2ChEMBLNo stored yeast mapping
NS1 · Nonstructural protein 1ChEMBLNo stored yeast mapping
TDP1 · Tyrosyl-DNA phosphodiesterase 1ChEMBLTDP1 YBR223C (ortholog_one2one)
TSHR · Thyrotropin receptorChEMBLNo stored yeast mapping

Structural activity predictions and SONAR

Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.

SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.

Open the complete 1-(4-chlorophenyl)-5-(2,3-dihydro-1,4-benzodioxin-6-yl)-6-ethyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one research profile →

Sources and provenance

Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.

Card snapshot: 2026-11-02. Linked interactive views may contain newer data.