CHEMGRID MOLECULE CARD
4-(2-methoxyphenyl)-1-(2-naphthylmethyl)piperidine
4-(2-methoxyphenyl)-1-(2-naphthylmethyl)piperidine in ChemGrid: 50 screened assays, 5 with significant responses. Explore chemical identifiers, strain activity and target evidence.
BTB 14604
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- BTB 14604
- Molecular formula
- C23H25NO
- InChIKey
- GWQBBMQQRFARIX-UHFFFAOYSA-N
- Libraries
- Maybridge1000
- Other recorded names
- 4-(2-Methoxyphenyl)-1-(naphthalen-2-ylmethyl)piperidine
Stored SMILES
COc1ccccc1C1CCN(CC1)Cc1ccc2ccccc2c1Matched external records: PubChem 2802693
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
50 measurements across 50 distinct library–species–strain assays; 5 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| slt2 | Maybridge1000 | 4932 | -6.04 |
| Peu18 | Maybridge1000 | 4932 | -6.01 |
| BY4741 | Maybridge1000 | 4932 | -5.26 |
| WT-Ciclosporin | Maybridge1000 | 4932 | -4.65 |
| TOP1 | Maybridge1000 | 4932 | -4.62 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| APOBEC3F · DNA dC->dU-editing enzyme APOBEC-3F | ChEMBL | No stored yeast mapping |
| ATXN2 · Ataxin-2 | ChEMBL | No stored yeast mapping |
| GLP1R · Glucagon-like peptide 1 receptor | ChEMBL | No stored yeast mapping |
| GMNN · Geminin | ChEMBL | No stored yeast mapping |
| IDH1 · Isocitrate dehydrogenase [NADP] cytoplasmic | ChEMBL | IDP1 YDL066W (ortholog_many2many); IDP2 YLR174W (ortholog_many2many); IDP3 YNL009W (ortholog_many2many) |
| KDM4A · Lysine-specific demethylase 4A | ChEMBL | YJR119C (ortholog_one2many) |
| MEN1 · Menin/Histone-lysine N-methyltransferase MLL | ChEMBL | No stored yeast mapping |
| POLI · DNA polymerase iota | ChEMBL | No stored yeast mapping |
| SMAD3 · Mothers against decapentaplegic homolog 3 | ChEMBL | No stored yeast mapping |
| TDP1 · Tyrosyl-DNA phosphodiesterase 1 | ChEMBL | TDP1 YBR223C (ortholog_one2one) |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete 4-(2-methoxyphenyl)-1-(2-naphthylmethyl)piperidine research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.