CHEMGRID MOLECULE CARD

N-(4-bromo-5-methylisoxazol-3-yl)-N`-(2-chloro-6-fluorobenzoyl)urea

N-(4-bromo-5-methylisoxazol-3-yl)-N`-(2-chloro-6-fluorobenzoyl)urea in ChemGrid: 50 screened assays, 1 with significant responses. Explore chemical identifiers, strain activity and target evidence.

BTB 05841

Explore activity & SONAR

Chemical structure of N-(4-bromo-5-methylisoxazol-3-yl)-N`-(2-chloro-6-fluorobenzoyl)urea — Stored molecular structure

50Screened assays

1Significant assay responses

3Source-labelled target records

Identity and chemistry

ChemGrid identifier: BTB 05841
Molecular formula: BrC12ClFH8N3O3
InChIKey: AXAGOKRWVYVJKG-UHFFFAOYSA-N
Libraries: Maybridge1000
Other recorded names: N-(4-bromo-5-methylisoxazol-3-yl)-N'-(2-chloro-6-fluorobenzoyl)urea

Stored SMILES

Cc1onc(NC(=O)NC(=O)c2c(F)cccc2Cl)c1Br

Matched external records: PubChem 2799364

Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.

Measured chemical–genetic activity

50 measurements across 50 distinct library–species–strain assays; 1 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).

Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.

Up to 12 strongest recorded single-strain responses by absolute Z-score
Strain	Library	Species identifier	Z-score
cin2	Maybridge1000	4932	-40.66

Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.

Recorded target evidence and yeast matches

Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.

Target	Source	Yeast ORF / orthologue
CGA · Glycoprotein hormones alpha chain	ChEMBL	No stored yeast mapping
GLP1R · Glucagon-like peptide 1 receptor	ChEMBL	No stored yeast mapping
TGR · Thioredoxin glutathione reductase	ChEMBL	TRR1 YDR353W (ortholog_many2many); TRR2 YHR106W (ortholog_many2many)

Structural activity predictions and SONAR

Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.

SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.

Open the complete N-(4-bromo-5-methylisoxazol-3-yl)-N`-(2-chloro-6-fluorobenzoyl)urea research profile →

Sources and provenance

Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.

Card snapshot: 2026-11-02. Linked interactive views may contain newer data.