ChemGrid

CHEMGRID MOLECULE CARD

4-chloro-2-nitro-1-(phenylsulfonyl)benzene

4-chloro-2-nitro-1-(phenylsulfonyl)benzene in ChemGrid: 50 screened assays, 9 with significant responses. Explore chemical identifiers, strain activity and target evidence.

BTB 02874

Explore activity & SONAR
Chemical structure of 4-chloro-2-nitro-1-(phenylsulfonyl)benzene
Stored molecular structure
50Screened assays
9Significant assay responses
1Source-labelled target records

Identity and chemistry

ChemGrid identifier
BTB 02874
Molecular formula
C12ClH8NO4S
InChIKey
VZDUQPHKUBZMLW-UHFFFAOYSA-N
Libraries
Maybridge1000
Other recorded names
1-Benzenesulfonyl-4-chloro-2-nitro-benzene
Stored SMILES[O-][N+](=O)c1cc(Cl)ccc1S(=O)(=O)c1ccccc1

Matched external records: PubChem 291461

Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.

Measured chemical–genetic activity

50 measurements across 50 distinct library–species–strain assays; 9 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).

Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.

Up to 12 strongest recorded single-strain responses by absolute Z-score
StrainLibrarySpecies identifierZ-score
CHRA24Maybridge10004932-8.13
TOP1Maybridge10004932-8.11
But24Maybridge10004932-7.32
ric1Maybridge10004932-7.01
ypt6Maybridge10004932-6.43
Peu18Maybridge10004932-4.81
But18Maybridge10004932-4.45
MT2481-pdr1pdr3Maybridge10004932-4.36
Leo18hMaybridge10004932-4.07

Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.

Recorded target evidence and yeast matches

Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.

TargetSourceYeast ORF / orthologue
KIF18A · Kinesin-like protein KIF18AChEMBLNo stored yeast mapping

Structural activity predictions and SONAR

Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.

SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.

Open the complete 4-chloro-2-nitro-1-(phenylsulfonyl)benzene research profile →

Sources and provenance

Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.

Card snapshot: 2026-11-02. Linked interactive views may contain newer data.