CHEMGRID MOLECULE CARD
1-methyl-2-(5-nitro-2-thienyl)-1,2,3,4-tetrahydroquinazolin-4-one
1-methyl-2-(5-nitro-2-thienyl)-1,2,3,4-tetrahydroquinazolin-4-one in ChemGrid: 50 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
BTB 02134
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- BTB 02134
- Molecular formula
- C13H11N3O3S
- InChIKey
- DSEZEYASLFCOFQ-UHFFFAOYSA-N
- Libraries
- Maybridge1000
- Other recorded names
- 2,3-Dihydro-1-methyl-2-(5-nitro-2-thienyl)-4(1H)-quinazolinone
Stored SMILES
[O-][N+](=O)c1sc(cc1)C1NC(=O)c2ccccc2N1CMatched external records: PubChem 328916
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
50 measurements across 50 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| APEX1 · DNA repair nuclease/redox regulator APEX1 | ChEMBL | No stored yeast mapping |
| ATAD5 · ATPase family AAA domain-containing protein 5 | ChEMBL | No stored yeast mapping |
| GMNN · Geminin | ChEMBL | No stored yeast mapping |
| MBNL1 · Muscleblind-like protein 1 | ChEMBL | No stored yeast mapping |
| PKM · Pyruvate kinase PKM | ChEMBL | CDC19 YAL038W (ortholog_many2many); PYK2 YOR347C (ortholog_many2many) |
| POLI · DNA polymerase iota | ChEMBL | No stored yeast mapping |
| TDP1 · Tyrosyl-DNA phosphodiesterase 1 | ChEMBL | TDP1 YBR223C (ortholog_one2one) |
| vpr · Aberrant vpr protein | ChEMBL | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete 1-methyl-2-(5-nitro-2-thienyl)-1,2,3,4-tetrahydroquinazolin-4-one research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.