CHEMGRID MOLECULE CARD
2-{4-[2-nitro-4-(trifluoromethyl)phenyl]piperazino}-1-ethanol
2-{4-[2-nitro-4-(trifluoromethyl)phenyl]piperazino}-1-ethanol in ChemGrid: 50 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
AW 01274
Explore activity & SONAR![Chemical structure of 2-{4-[2-nitro-4-(trifluoromethyl)phenyl]piperazino}-1-ethanol](/structure-thumbnails/Maybridge1000/AW/AW_01274.svg?v=2026-09-22T13%3A54%3A31%2B00%3A00)
Identity and chemistry
- ChemGrid identifier
- AW 01274
- Molecular formula
- C13F3H16N3O3
- InChIKey
- CSQYNPKWTDSSNB-UHFFFAOYSA-N
- Libraries
- Maybridge1000
- Other recorded names
- 2-[4-[2-Nitro-4-(trifluoromethyl)phenyl]piperazino]-1-ethanol
Stored SMILES
[O-][N+](=O)c1cc(ccc1N1CCN(CCO)CC1)C(F)(F)FMatched external records: PubChem 2775795
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
50 measurements across 50 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| POLI · DNA polymerase iota | ChEMBL | No stored yeast mapping |
| PTH1R · Parathyroid hormone/parathyroid hormone-related peptide receptor | ChEMBL | No stored yeast mapping |
| RAN · GTP-binding nuclear protein Ran/Importin subunit beta-1/Snurportin-1 | ChEMBL | GSP1 YLR293C (ortholog_one2many); GSP2 YOR185C (ortholog_one2many) |
| SMAD3 · Mothers against decapentaplegic homolog 3 | ChEMBL | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete 2-{4-[2-nitro-4-(trifluoromethyl)phenyl]piperazino}-1-ethanol research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.