CHEMGRID MOLECULE CARD
1-Phenyl-4-[4-(phenylsulfonyl)piperazin-1-yl]phthalazine
1-Phenyl-4-[4-(phenylsulfonyl)piperazin-1-yl]phthalazine in ChemGrid: 3 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
6434-3649
Explore activity & SONAR![Chemical structure of 1-Phenyl-4-[4-(phenylsulfonyl)piperazin-1-yl]phthalazine](/structure-thumbnails/ChemDiv-Kinase/64/6434-3649.svg?v=2026-09-22T13%3A54%3A31%2B00%3A00)
Identity and chemistry
- ChemGrid identifier
- 6434-3649
- Molecular formula
- C24H22N4O2S
- InChIKey
- WXICTVPGBGMLIC-UHFFFAOYSA-N
- Libraries
- ChemDiv-Kinase
Stored SMILES
O=S(=O)(N1CCN(CC1)c1nnc(c2ccccc2)c2ccccc21)c1ccccc1Matched external records: PubChem 6407290
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
3 measurements across 3 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| ATAD5 · ATPase family AAA domain-containing protein 5 | ChEMBL | No stored yeast mapping |
| EYA2 · Protein phosphatase EYA2 | ChEMBL | No stored yeast mapping |
| GAA · Lysosomal alpha-glucosidase | ChEMBL | ROT2 YBR229C (ortholog_one2many) |
| GNAS · Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | ChEMBL | GPA2 YER020W (ortholog_many2many); GPA1 YHR005C (ortholog_many2many) |
| NFE2L2 · Nuclear factor erythroid 2-related factor 2 | ChEMBL | No stored yeast mapping |
| NPSR1 · Neuropeptide S receptor | ChEMBL | No stored yeast mapping |
| PTH1R · Parathyroid hormone/parathyroid hormone-related peptide receptor | ChEMBL | No stored yeast mapping |
| TDP1 · Tyrosyl-DNA phosphodiesterase 1 | ChEMBL | TDP1 YBR223C (ortholog_one2one) |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete 1-Phenyl-4-[4-(phenylsulfonyl)piperazin-1-yl]phthalazine research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.