CHEMGRID MOLECULE CARD
N-(4-methylphenyl)-4-benzofuro[3,2-d]pyrimidinamine
N-(4-methylphenyl)-4-benzofuro[3,2-d]pyrimidinamine in ChemGrid: 3 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
3574-0114
Explore activity & SONAR![Chemical structure of N-(4-methylphenyl)-4-benzofuro[3,2-d]pyrimidinamine](/structure-thumbnails/ChemDiv-Kinase/35/3574-0114.svg?v=2026-09-22T13%3A54%3A31%2B00%3A00)
Identity and chemistry
- ChemGrid identifier
- 3574-0114
- Molecular formula
- C17H13N3O
- InChIKey
- CAZVRVVZXFTMFC-UHFFFAOYSA-N
- Libraries
- ChemDiv-Kinase
Stored SMILES
Cc1ccc(Nc2ncnc3c2oc2ccccc23)cc1Matched external records: PubChem 1398093
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
3 measurements across 3 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| Luciferin 4-monooxygenase | ChEMBL | No stored yeast mapping |
| ampC · Beta-lactamase | ChEMBL | No stored yeast mapping |
| ATAD5 · ATPase family AAA domain-containing protein 5 | ChEMBL | No stored yeast mapping |
| NPC1 · NPC intracellular cholesterol transporter 1 | ChEMBL | NCR1 YPL006W (ortholog_one2one) |
| NS1 · Nonstructural protein 1 | ChEMBL | No stored yeast mapping |
| PTH1R · Parathyroid hormone/parathyroid hormone-related peptide receptor | ChEMBL | No stored yeast mapping |
| RAB9A · Ras-related protein Rab-9A | ChEMBL | YPT10 YBR264C (ortholog_many2many); YPT31 YER031C (ortholog_many2many); YPT1 YFL038C (ortholog_many2many); YPT32 YGL210W (ortholog_many2many); YPT52 YKR014C (ortholog_many2many); YPT6 YLR262C (ortholog_many2many); TEM1 YML064C (ortholog_many2many) |
| SENP6 · Sentrin-specific protease 6 | ChEMBL | ULP2 YIL031W (ortholog_one2many) |
| SENP8 · Sentrin-specific protease 8 | ChEMBL | No stored yeast mapping |
| TRPV1 · Transient receptor potential cation channel subfamily V member 1 | ChEMBL | YVC1 YOR087W (ortholog_one2many) |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete N-(4-methylphenyl)-4-benzofuro[3,2-d]pyrimidinamine research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.