CHEMGRID MOLECULE CARD
2-thiophen-2-yl-6,7,8,9-tetrahydro-5H-cyclohepta[2,3]thieno[2,4-b][1,3]oxazin-4-one
2-thiophen-2-yl-6,7,8,9-tetrahydro-5H-cyclohepta[2,3]thieno[2,4-b][1,3]oxazin-4-one in ChemGrid: 3 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
3487-1226
Explore activity & SONAR![Chemical structure of 2-thiophen-2-yl-6,7,8,9-tetrahydro-5H-cyclohepta[2,3]thieno[2,4-b][1,3]oxazin-4-one](/structure-thumbnails/ChemDiv-Kinase/34/3487-1226.svg?v=2026-09-22T13%3A54%3A31%2B00%3A00)
Identity and chemistry
- ChemGrid identifier
- 3487-1226
- Molecular formula
- C15H13NO2S2
- InChIKey
- GHXPLSBTZCUDSF-UHFFFAOYSA-N
- Libraries
- ChemDiv-Kinase
Stored SMILES
O=C1OC(=Nc2sc3CCCCCc3c12)c1sccc1Matched external records: PubChem 806210
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
3 measurements across 3 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| Luciferin 4-monooxygenase | ChEMBL | No stored yeast mapping |
| BRCA1 · Breast cancer type 1 susceptibility protein | ChEMBL | No stored yeast mapping |
| GNAS · Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | ChEMBL | GPA2 YER020W (ortholog_many2many); GPA1 YHR005C (ortholog_many2many) |
| HPGD · 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | ChEMBL | AYR1 YIL124W (ortholog_one2one) |
| HSD17B10 · 3-hydroxyacyl-CoA dehydrogenase type-2 | ChEMBL | No stored yeast mapping |
| lef · Lethal factor | ChEMBL | No stored yeast mapping |
| NPC1 · NPC intracellular cholesterol transporter 1 | ChEMBL | NCR1 YPL006W (ortholog_one2one) |
| POLI · DNA polymerase iota | ChEMBL | No stored yeast mapping |
| RAB9A · Ras-related protein Rab-9A | ChEMBL | YPT10 YBR264C (ortholog_many2many); YPT31 YER031C (ortholog_many2many); YPT1 YFL038C (ortholog_many2many); YPT32 YGL210W (ortholog_many2many); YPT52 YKR014C (ortholog_many2many); YPT6 YLR262C (ortholog_many2many); TEM1 YML064C (ortholog_many2many) |
| SMN1 · Survival motor neuron protein | ChEMBL | No stored yeast mapping |
| TP53 · Cellular tumor antigen p53 | ChEMBL | No stored yeast mapping |
| Cruzipain | ChEMBL analogue | No stored yeast mapping |
| Luciferin 4-monooxygenase | ChEMBL analogue | No stored yeast mapping |
| ALDH1A1 · Aldehyde dehydrogenase 1A1 | ChEMBL analogue | ALD5 YER073W (ortholog_many2many); ALD3 YMR169C (ortholog_many2many); ALD2 YMR170C (ortholog_many2many); ALD4 YOR374W (ortholog_many2many); ALD6 YPL061W (ortholog_many2many) |
| ATAD5 · ATPase family AAA domain-containing protein 5 | ChEMBL analogue | No stored yeast mapping |
| GMNN · Geminin | ChEMBL analogue | No stored yeast mapping |
| HPGD · 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | ChEMBL analogue | AYR1 YIL124W (ortholog_one2one) |
| KPNB1 · Importin subunit beta-1/Snurportin-1 | ChEMBL analogue | KAP95 YLR347C (ortholog_one2one) |
| MAPT · Microtubule-associated protein tau | ChEMBL analogue | No stored yeast mapping |
| Rorc · Nuclear receptor ROR-gamma | ChEMBL analogue | No stored yeast mapping |
| SMN1 · Survival motor neuron protein | ChEMBL analogue | No stored yeast mapping |
| Txnrd1 · Thioredoxin reductase 1, cytoplasmic | ChEMBL analogue | TRR1 YDR353W (ortholog_many2many); TRR2 YHR106W (ortholog_many2many) |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete 2-thiophen-2-yl-6,7,8,9-tetrahydro-5H-cyclohepta[2,3]thieno[2,4-b][1,3]oxazin-4-one research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.