CHEMGRID MOLECULE CARD

Methyl 3-[[6,6-dimethyl-3-(2-methylprop-2-enyl)-4-oxo-5,8-dihydropyrano[2,3]thieno[2,4-b]pyrimidin-2-yl]sulfanyl]propanoate

Methyl 3-[[6,6-dimethyl-3-(2-methylprop-2-enyl)-4-oxo-5,8-dihydropyrano[2,3]thieno[2,4-b]pyrimidin-2-yl]sulfanyl]propanoate in ChemGrid: 3 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.

3473-1014

Explore activity & SONAR

Chemical structure of Methyl 3-[[6,6-dimethyl-3-(2-methylprop-2-enyl)-4-oxo-5,8-dihydropyrano[2,3]thieno[2,4-b]pyrimidin-2-yl]sulfanyl]propanoate — Stored molecular structure

3Screened assays

0Significant assay responses

1Source-labelled target records

Identity and chemistry

ChemGrid identifier: 3473-1014
Molecular formula: C19H24N2O4S2
InChIKey: PSWWYXKRLRSSPB-UHFFFAOYSA-N
Libraries: ChemDiv-Kinase

Stored SMILES

COC(=O)CCSC1=Nc2sc3COC(C)(C)Cc3c2C(=O)N1CC(C)=C

Matched external records: PubChem 1042944

Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.

Measured chemical–genetic activity

3 measurements across 3 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).

Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.

Recorded target evidence and yeast matches

Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.

Target	Source	Yeast ORF / orthologue
SAMHD1 · Deoxynucleoside triphosphate triphosphohydrolase SAMHD1	ChEMBL	No stored yeast mapping

Structural activity predictions and SONAR

Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.

SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.

Open the complete Methyl 3-[[6,6-dimethyl-3-(2-methylprop-2-enyl)-4-oxo-5,8-dihydropyrano[2,3]thieno[2,4-b]pyrimidin-2-yl]sulfanyl]propanoate research profile →

Sources and provenance

Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.

Card snapshot: 2026-11-02. Linked interactive views may contain newer data.