CHEMGRID MOLECULE CARD
2-Quinolin-6-yl-benzo[de]isoquinoline-1,3-dione
2-Quinolin-6-yl-benzo[de]isoquinoline-1,3-dione in ChemGrid: 3 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
3389-2203
Explore activity & SONAR![Chemical structure of 2-Quinolin-6-yl-benzo[de]isoquinoline-1,3-dione](/structure-thumbnails/ChemDiv-Kinase/33/3389-2203.svg?v=2026-09-22T13%3A54%3A31%2B00%3A00)
Identity and chemistry
- ChemGrid identifier
- 3389-2203
- Molecular formula
- C21H12N2O2
- InChIKey
- AQTWMUUOCRXCPX-UHFFFAOYSA-N
- Libraries
- ChemDiv-Kinase
Stored SMILES
O=C1N(c2ccc3ncccc3c2)C(=O)c2cccc3cccc1c32Matched external records: PubChem 2055089
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
3 measurements across 3 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| Cruzipain | ChEMBL | No stored yeast mapping |
| EHMT2 · Histone-lysine N-methyltransferase EHMT2 | ChEMBL | SET2 YJL168C (ortholog_many2many) |
| F2 · Prothrombin | ChEMBL | No stored yeast mapping |
| ffp · 4'-phosphopantetheinyl transferase ffp | ChEMBL | No stored yeast mapping |
| KDM4A · Lysine-specific demethylase 4A | ChEMBL | YJR119C (ortholog_one2many) |
| MMP2 · 72 kDa type IV collagenase | ChEMBL | No stored yeast mapping |
| POLB · DNA polymerase beta | ChEMBL | No stored yeast mapping |
| PSMD14 · 26S proteasome non-ATPase regulatory subunit 14 | ChEMBL | RPN11 YFR004W (ortholog_one2one) |
| Rorc · Nuclear receptor ROR-gamma | ChEMBL | No stored yeast mapping |
| TP53 · Cellular tumor antigen p53 | ChEMBL | No stored yeast mapping |
| WRN · Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN | ChEMBL | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete 2-Quinolin-6-yl-benzo[de]isoquinoline-1,3-dione research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.