CHEMGRID MOLECULE CARD
2-[3-[3-[3-(1-Imidazolyl)propyl]-4-oxo-2-quinazolinyl]propyl]isoindole-1,3-dione
2-[3-[3-[3-(1-Imidazolyl)propyl]-4-oxo-2-quinazolinyl]propyl]isoindole-1,3-dione in ChemGrid: 3 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
3126-2088
Explore activity & SONAR![Chemical structure of 2-[3-[3-[3-(1-Imidazolyl)propyl]-4-oxo-2-quinazolinyl]propyl]isoindole-1,3-dione](/structure-thumbnails/ChemDiv-Kinase/31/3126-2088.svg?v=2026-09-22T13%3A54%3A31%2B00%3A00)
Identity and chemistry
- ChemGrid identifier
- 3126-2088
- Molecular formula
- C25H23N5O3
- InChIKey
- YBNRLCUXQBXSJX-UHFFFAOYSA-N
- Libraries
- ChemDiv-Kinase
Stored SMILES
O=C1N(CCCn2ccnc2)C(CCCn2c(=O)c3ccccc3c2=O)=Nc2ccccc12Matched external records: PubChem 644964
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
3 measurements across 3 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| Cruzipain | ChEMBL | No stored yeast mapping |
| ALOX15 · Polyunsaturated fatty acid lipoxygenase ALOX15 | ChEMBL | No stored yeast mapping |
| ALOX15B · Polyunsaturated fatty acid lipoxygenase ALOX15B | ChEMBL | No stored yeast mapping |
| ampC · Beta-lactamase | ChEMBL | No stored yeast mapping |
| EHMT2 · Histone-lysine N-methyltransferase EHMT2 | ChEMBL | SET2 YJL168C (ortholog_many2many) |
| ESR1 · Estrogen receptor | ChEMBL | No stored yeast mapping |
| GLS · Glutaminase kidney isoform, mitochondrial | ChEMBL | No stored yeast mapping |
| GNAS · Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | ChEMBL | GPA2 YER020W (ortholog_many2many); GPA1 YHR005C (ortholog_many2many) |
| HSD17B10 · 3-hydroxyacyl-CoA dehydrogenase type-2 | ChEMBL | No stored yeast mapping |
| KDM4A · Lysine-specific demethylase 4A | ChEMBL | YJR119C (ortholog_one2many) |
| POLH · DNA polymerase eta | ChEMBL | RAD30 YDR419W (ortholog_one2one) |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete 2-[3-[3-[3-(1-Imidazolyl)propyl]-4-oxo-2-quinazolinyl]propyl]isoindole-1,3-dione research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.