CHEMGRID MOLECULE CARD

2-Dimethylamino-6,7-dihydro-oxazolo[3,2-a][1,3,5]triazin-4-one

2-Dimethylamino-6,7-dihydro-oxazolo[3,2-a][1,3,5]triazin-4-one in ChemGrid: 3 screened assays, 1 with significant responses. Explore chemical identifiers, strain activity and target evidence.

2994-5667

Explore activity & SONAR

Chemical structure of 2-Dimethylamino-6,7-dihydro-oxazolo[3,2-a][1,3,5]triazin-4-one — Stored molecular structure

3Screened assays

1Significant assay responses

5Source-labelled target records

Identity and chemistry

ChemGrid identifier: 2994-5667
Molecular formula: C7H10N4O2
InChIKey: CIPMVXYZLWSEDR-UHFFFAOYSA-N
Libraries: ChemDiv-Kinase

Stored SMILES

CN(C)C1=NC(=O)N2CCOC2=N1

Matched external records: PubChem 602681

Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.

Measured chemical–genetic activity

3 measurements across 3 distinct library–species–strain assays; 1 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).

Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.

Up to 12 strongest recorded single-strain responses by absolute Z-score
Strain	Library	Species identifier	Z-score
tep1-2nd	ChemDiv-Kinase	4932	-6.98

Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.

Recorded target evidence and yeast matches

Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.

Target	Source	Yeast ORF / orthologue
ampC · Beta-lactamase	ChEMBL	No stored yeast mapping
GNAS · Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	ChEMBL	GPA2 YER020W (ortholog_many2many); GPA1 YHR005C (ortholog_many2many)
KPNB1 · Importin subunit beta-1/Snurportin-1	ChEMBL	KAP95 YLR347C (ortholog_one2one)
POLI · DNA polymerase iota	ChEMBL	No stored yeast mapping
USP1 · Ubiquitin carboxyl-terminal hydrolase 1	ChEMBL	UBP13 YBL067C (ortholog_many2many); UBP9 YER098W (ortholog_many2many); UBP8 YMR223W (ortholog_many2many); UBP2 YOR124C (ortholog_many2many)

Structural activity predictions and SONAR

Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.

SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.

Open the complete 2-Dimethylamino-6,7-dihydro-oxazolo[3,2-a][1,3,5]triazin-4-one research profile →

Sources and provenance

Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.

Card snapshot: 2026-11-02. Linked interactive views may contain newer data.