CHEMGRID MOLECULE CARD
3-(2H,3H,4H-benzo[b]1,4-dioxepin-7-yl)-5,7-dihydroxychromen-4-one
3-(2H,3H,4H-benzo[b]1,4-dioxepin-7-yl)-5,7-dihydroxychromen-4-one in ChemGrid: 3 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
2188-2624
Explore activity & SONAR![Chemical structure of 3-(2H,3H,4H-benzo[b]1,4-dioxepin-7-yl)-5,7-dihydroxychromen-4-one](/structure-thumbnails/ChemDiv-Kinase/21/2188-2624.svg?v=2026-09-22T13%3A54%3A31%2B00%3A00)
Identity and chemistry
- ChemGrid identifier
- 2188-2624
- Molecular formula
- C18H14O6
- InChIKey
- GKQZRSBHTVASBV-UHFFFAOYSA-N
- Libraries
- ChemDiv-Kinase
Stored SMILES
Oc1cc(O)c2C(=O)C(=COc2c1)c1ccc2OCCCOc2c1Matched external records: PubChem 5413007
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
3 measurements across 3 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| ALOX12 · Polyunsaturated fatty acid lipoxygenase ALOX12 | ChEMBL analogue | No stored yeast mapping |
| FPR1 · fMet-Leu-Phe receptor | ChEMBL analogue | No stored yeast mapping |
| NPC1 · NPC intracellular cholesterol transporter 1 | ChEMBL analogue | NCR1 YPL006W (ortholog_one2one) |
| NPSR1 · Neuropeptide S receptor | ChEMBL analogue | No stored yeast mapping |
| NS1 · Nonstructural protein 1 | ChEMBL analogue | No stored yeast mapping |
| RAB9A · Ras-related protein Rab-9A | ChEMBL analogue | YPT10 YBR264C (ortholog_many2many); YPT31 YER031C (ortholog_many2many); YPT1 YFL038C (ortholog_many2many); YPT32 YGL210W (ortholog_many2many); YPT52 YKR014C (ortholog_many2many); YPT6 YLR262C (ortholog_many2many); TEM1 YML064C (ortholog_many2many) |
| Rorc · Nuclear receptor ROR-gamma | ChEMBL analogue | No stored yeast mapping |
| TIM10 · Mitochondrial import inner membrane translocase subunit TIM10 | ChEMBL analogue | MRS5 YBR091C (ortholog_one2many); MRS11 YHR005C-A (ortholog_one2many) |
| TIM23 · Mitochondrial import inner membrane translocase subunit TIM23 | ChEMBL analogue | MAS6 YNR017W (ortholog_one2many) |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete 3-(2H,3H,4H-benzo[b]1,4-dioxepin-7-yl)-5,7-dihydroxychromen-4-one research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.