CHEMGRID MOLECULE CARD
3-(4-Ethyl-1-piperazinyl)-5-methylpyridazino[3,4-b][1,4]benzoxazine
3-(4-Ethyl-1-piperazinyl)-5-methylpyridazino[3,4-b][1,4]benzoxazine in ChemGrid: 3 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
000A-0221
Explore activity & SONAR![Chemical structure of 3-(4-Ethyl-1-piperazinyl)-5-methylpyridazino[3,4-b][1,4]benzoxazine](/structure-thumbnails/ChemDiv-Kinase/00/000A-0221.svg?v=2026-09-22T13%3A54%3A31%2B00%3A00)
Identity and chemistry
- ChemGrid identifier
- 000A-0221
- Molecular formula
- C17H21N5O
- InChIKey
- WCZLZKLICVOKBC-UHFFFAOYSA-N
- Libraries
- ChemDiv-Kinase
Stored SMILES
CCN1CCN(CC1)c1cc2N(C)c3ccccc3Oc2nn1Matched external records: PubChem 2832013
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
3 measurements across 3 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| Luciferin 4-monooxygenase | ChEMBL | No stored yeast mapping |
| ALDH1A1 · Aldehyde dehydrogenase 1A1 | ChEMBL | ALD5 YER073W (ortholog_many2many); ALD3 YMR169C (ortholog_many2many); ALD2 YMR170C (ortholog_many2many); ALD4 YOR374W (ortholog_many2many); ALD6 YPL061W (ortholog_many2many) |
| clpP · ATP-dependent Clp protease proteolytic subunit | ChEMBL | No stored yeast mapping |
| EHMT2 · Histone-lysine N-methyltransferase EHMT2 | ChEMBL | SET2 YJL168C (ortholog_many2many) |
| MBNL1 · Muscleblind-like protein 1 | ChEMBL | No stored yeast mapping |
| RAB9A · Ras-related protein Rab-9A | ChEMBL | YPT10 YBR264C (ortholog_many2many); YPT31 YER031C (ortholog_many2many); YPT1 YFL038C (ortholog_many2many); YPT32 YGL210W (ortholog_many2many); YPT52 YKR014C (ortholog_many2many); YPT6 YLR262C (ortholog_many2many); TEM1 YML064C (ortholog_many2many) |
| SMN1 · Survival motor neuron protein | ChEMBL | No stored yeast mapping |
| SMPD1 · Sphingomyelin phosphodiesterase | ChEMBL | PPN1 YDR452W (ortholog_one2many) |
| Txnrd1 · Thioredoxin reductase 1, cytoplasmic | ChEMBL | TRR1 YDR353W (ortholog_many2many); TRR2 YHR106W (ortholog_many2many) |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete 3-(4-Ethyl-1-piperazinyl)-5-methylpyridazino[3,4-b][1,4]benzoxazine research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.