Description: One of two isozymes of HMG-CoA reductase that catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; localizes to the nuclear envelope; overproduction induces the formation of karmellae
Function: 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase isozyme
