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taxon	orf/entrez	description	information	symbol
4932	YDL020C	Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses	Null mutant is viable, exhibits synthetic interactions with sen3, sun1, and cdc28-1N	RPN4
4932	YGL020C	Subunit of the GET complex; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for normal mitochondrial morphology and inheritance	Null: Required for spore wall formation, but not IME1 induction or nuclear division	GET1
4932	YGL212W	Component of the vacuole SNARE complex involved in vacuolar morphogenesis; SNAP-25 homolog; functions with a syntaxin homolog Vam3p in vacuolar protein trafficking	Null mutant is viable, exhibits prominent large vacuoles	VAM7
4932	YGR105W	Integral membrane protein that is required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER)	Null mutant is viable but grows slowly and exhibits increased calcium sensitivity. Null mutants also cannot grow on glycerol or at pH 7.5	VMA21
4932	YGR106C	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar memebrane		YGR106C
4932	YGR120C	Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments	Null mutant shows severe growth defect at 30 degrees and is inviable at 21 degrees; sec35-1 allele is temperature-sensitive for growth	COG2
4932	YHL027W	Transcriptional repressor involved in response to pH and in cell wall construction; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by proteolytic processing; similar to A. nidulans PacC	Poor growth at low temperature, altered colony morphology, inefficient sporulation due to reduced expression of the meiotic activator IME1, and defective invasive growth	RIM101
4932	YHR200W	Non-ATPase base subunit of the 19S regulatory particle (RP) of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the RP; binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein	Null mutant is viable, exhibits a modest sensitivity to amino acid analogs and has increased steady-state levels of ubiquitin-protein conjugates	RPN10
4932	YJL081C	Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes		ARP4
4932	YJR066W	PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis	Null mutant is viable, grows slowly; rapamycin resistance, tor1 tor2 double mutant is inviable	TOR1
4932	YLR039C	Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes	defective in the transcription of both ribosomal protein genes and ribosomal RNA	RIC1
4932	YLR148W	Component of CORVET tethering complex; vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesis	Null mutant is viable, exhibits growth defects at 37 degrees celsius, exhibits vacuolar protein sorting and processing and defects, exhibits decreased levels of protease A, protease B, and carboxylpeptidase Y antigens; decreased repressible alkaline phosphatase activity; null mutants contain very few normal vacuolelike organelles; homozygous null mutants are sporulation defective	PEP3
4932	YLR153C	Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions	Null mutant is viable, and grows on ethanol or acetate as sole carbon source, but is unable to grow on glucose as sole carbon source; acs1 acs2 double null mutant is inviable	ACS2
4932	YLR262C	GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6	Null mutant is viable, temperature sensitive; suppressed by ssd1 and imh1 mutations	YPT6
4932	YMR186W	Cytoplasmic chaperone of the Hsp90 family, redundant in function and nearly identical with Hsp82p, and together they are essential; expressed constitutively at 10-fold higher basal levels that HSP82 and induced 2-3 fold by heat shock	Null mutant is viable at 25 degrees C; ability to grow at higher temperatures varies with gene copy number	HSC82
4932	YMR319C	Low-affinity Fe(II) transporter of the plasma membrane	Mutant lacks low affinity Fe(II) transport but has more active high affinity Fe(II) transport activity	FET4
4932	YNL243W	Transmembrane actin-binding protein involved in membrane cytoskeleton assembly and cell polarization; adaptor protein that links actin to clathrin and endocytosis; present in the actin cortical patch of the emerging bud tip; dimer in vivo	Null mutant is viable and temperature sensitive	SLA2
4932	YOR036W	Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin	proteinase deficient	PEP12
4932	YOR070C	Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion	Null mutant is viable and shows no phenotype	GYP1
4932	YPL153C	Protein kinase, required for cell-cycle arrest in response to DNA damage; activated by trans autophosphorylation when interacting with hyperphosphorylated Rad9p; also interacts with ARS1 and plays a role in initiation of DNA replication	Null mutant is inviable, radiation sensitive	RAD53
4932	YPL240C	Cytoplasmic chaperone (Hsp90 family) required for pheromone signaling and negative regulation of Hsf1p; docks with the mitochondrial import receptor Tom70p for preprotein delivery; interacts with co-chaperones Cns1p, Cpr6p, Cpr7p, and Sti1p	Null mutant is viable at 25 degrees C; ability to grow at higher temperatures varies with gene copy number	HSC82