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taxon	orf/entrez	description	information	symbol
4932	YDL020C	Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses	Null mutant is viable, exhibits synthetic interactions with sen3, sun1, and cdc28-1N	RPN4
4932	YDL040C	Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing	Null mutant is viable, has reduced acetyltransferase activity, derepressed silent mating type locus (HML) and fails to enter G0	NAT1
4932	YDL074C	E3 ubiquitin ligase for Rad6p, required for the ubiquitination of histone H2B, recruitment of Rad6p to promoter chromatin and subsequent methylation of histone H3 (on K4 and K79), contains RING finger domain	null mutant is sensitive to brefeldin A	BRE1
4932	YDR359C	Component of the NuA4 histone acetyltransferase complex		EAF1
4932	YDR485C	Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting	Null mutant secretes CPY.	VPS72
4932	YEL061C	Kinesin motor protein involved in mitotic spindle assembly and chromosome segregation	Null mutant is viable; cin8 dyn1 and cin8 kip1 double deletion mutants are inviable	CIN8
4932	YER016W	Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally	Null mutant is viable, causes cold sensitivity, benomyl supersensitivity, aberrant microtubule morphology. During mitosis in bim1 mutants, the nucleus fails to move to the mother-bud neck.	BIM1
4932	YER083C	Subunit of the GET complex; required for meiotic nuclear division and for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion; may be involved in cell wall function	null is hypersensitive to calcofluor white suffer an increased spheroplast lysis rate	GET2
4932	YGL020C	Subunit of the GET complex; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for normal mitochondrial morphology and inheritance	Null: Required for spore wall formation, but not IME1 induction or nuclear division	GET1
4932	YGL058W	Ubiquitin-conjugating enzyme (E2), involved in postreplication repair (with Rad18p), sporulation, telomere silencing, and ubiquitin-mediated N-end rule protein degradation (with Ubr1p)	Radiation sensitive. Defective for postreplication repair, repression of retrotransposition, meiotic gene conversion and sporulation. Mutations in srs2 suppress rad6 radiation-sensitivity but not the sporulation defect. rad6 forms recombination intermediates. mgs1 is synthetic lethal with rad6.; Deletion mutants of this post-replication repair (PRR) gene do not have any cross-link-induced mutations but show increased levels of recombination.	RAD6
4932	YGR078C	Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding	Null mutant is viable, benomyl sensitive, cold sensitive, microtubules disassemble at 14 degrees celsius, pac10 mutants exhibit synthetic lethality with tub4-1, cin8, cin1, pac2 and rbl2 mutants	PAC10
4932	YHR013C	Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing		ARD1
4932	YHR191C	Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion		CTF8
4932	YJL030W	Component of the spindle-assembly checkpoint complex, which delays the onset of anaphase in cells with defects in mitotic spindle assembly; forms a complex with Mad1p		MAD2
4932	YJL115W	Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed		ASF1
4932	YLR085C	Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A		ARP6
4932	YLR200W	Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin		YKE2
4932	YML094W	Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it	Null mutant is viable, cold sensitive, benomyl and nocadazole sensitive and fails to grow on YPD+1.2M KCl or YPD+1.8M sorbitol; synthetically lethal with tub4-1 mutations	GIM5
4932	YMR078C	Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint	Null mutant is viable, exhibits increased level of spontaneous mitotic recombination, slow growth, and cold sensitivity	CTF18
4932	YOL012C	Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin	Null mutant is viable at 28C; high copy suppressor of histone H4 point mutant affecting nucleosome structure	HTZ1
4932	YOR244W	Histone acetyltransferase catalytic subunit of the native multisubunit complex (NuA4) that acetylates four conserved internal lysines of histone H4 N-terminal tail; required for cell cycle progression		ESA1
4932	YOR349W	Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl	Null mutant is viable, exhibits cold sensitivity for viability; defect in nuclear migration and nuclear fusion, supersensitivity to benomyl and nocodozole	CIN1
4932	YPL055C	Protein of unknown function; null mutant forms abnormally large cells	Null: large cell size. Other phenotypes: synthetic lethal with swi4	LGE1
4932	YPL240C	Cytoplasmic chaperone (Hsp90 family) required for pheromone signaling and negative regulation of Hsf1p; docks with the mitochondrial import receptor Tom70p for preprotein delivery; interacts with co-chaperones Cns1p, Cpr6p, Cpr7p, and Sti1p	Null mutant is viable at 25 degrees C; ability to grow at higher temperatures varies with gene copy number	HSC82
4932	YPR135W	Chromatin-associated protein, required for sister chromatid cohesion; interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesion	Null mutant is viable but shows increase in the rate of mitotic chromosome loss, increased mitotic recombination, shift toward cells with G2 DNA content, and large budded cells with the nucleus in the bud neck; shows synthetic interactions with rad52, pol1, rad9, and esr1	CTF4