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taxon	orf/entrez	description	information	symbol
4932	YAL024C	Putative GDP/GTP exchange factor required for mitotic exit at low temperatures; acts as a guanine nucleotide exchange factor (GEF) for Tem1p, which is a key regulator of mitotic exit; physically associates with Ras2p-GTP	lethal at low temperature (8 degrees C)	LTE1
4932	YCL016C	Subunit of a complex with Ctf8p and Ctf18p that shares some components with Replication Factor C, required for sister chromatid cohesion and telomere length maintenance	benomyl sensitive and defective in sister chromatid cohesion	DCC1
4932	YDL020C	Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses	Null mutant is viable, exhibits synthetic interactions with sen3, sun1, and cdc28-1N	RPN4
4932	YDL040C	Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing	Null mutant is viable, has reduced acetyltransferase activity, derepressed silent mating type locus (HML) and fails to enter G0	NAT1
4932	YER016W	Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally	Null mutant is viable, causes cold sensitivity, benomyl supersensitivity, aberrant microtubule morphology. During mitosis in bim1 mutants, the nucleus fails to move to the mother-bud neck.	BIM1
4932	YER083C	Subunit of the GET complex; required for meiotic nuclear division and for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion; may be involved in cell wall function	null is hypersensitive to calcofluor white suffer an increased spheroplast lysis rate	GET2
4932	YGL020C	Subunit of the GET complex; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for normal mitochondrial morphology and inheritance	Null: Required for spore wall formation, but not IME1 induction or nuclear division	GET1
4932	YGL058W	Ubiquitin-conjugating enzyme (E2), involved in postreplication repair (with Rad18p), sporulation, telomere silencing, and ubiquitin-mediated N-end rule protein degradation (with Ubr1p)	Radiation sensitive. Defective for postreplication repair, repression of retrotransposition, meiotic gene conversion and sporulation. Mutations in srs2 suppress rad6 radiation-sensitivity but not the sporulation defect. rad6 forms recombination intermediates. mgs1 is synthetic lethal with rad6.; Deletion mutants of this post-replication repair (PRR) gene do not have any cross-link-induced mutations but show increased levels of recombination.	RAD6
4932	YGR229C	Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity	Null mutant is viable, shows osmotic sensitivity, sensitivity to cercosporamide, resistance to zymolase; temperature sensitive mutant arrests at S phase with small buds	SMI1
4932	YHR013C	Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing		ARD1
4932	YHR030C	Serine/threonine MAP kinase involved in regulating the maintenance of cell wall integrity and progression through the cell cycle; regulated by the PKC1-mediated signaling pathway	Null mutant is viable but temperature sensitive. At elevated temperatures or in the presence of caffeine, mull mutants exhibit cell wall defects that result in cell lysis. Lysis is prevented by addition of 1M sorbitol.	SLT2
4932	YHR191C	Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion		CTF8
4932	YJL030W	Component of the spindle-assembly checkpoint complex, which delays the onset of anaphase in cells with defects in mitotic spindle assembly; forms a complex with Mad1p		MAD2
4932	YKL113C	5- to 3- exonuclease, 5- flap endonuclease, required for Okazaki fragment processing and maturation as well as for long-patch base-excision repair; member of the S. pombe RAD2/FEN1 family	Null mutant demonstrates temperature-sensitive growth and sensitivity to UV light and methylmethane sulfonate. rad27 mutant cells are defective in Okazaki fragment maturation.	RAD27
4932	YLR085C	Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A		ARP6
4932	YLR418C	Constituent of Paf1 complex with RNA polymerase II, Paf1p, Hpr1p, Ctr9, Leo1, Rtf1 and Ccr4p, distinct from Srb-containing Pol II complexes; required for expression of certain genes, modification of some histones, and telomere maintenance	Mutations affect cell growth and the abundance of transcripts from a subset of genes	CDC73
4932	YML032C	Protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis	Null mutant is viable, radiation sensitive; rad52 rad27 double mutants are inviable, double strand break ends are excessively recessed in mutant, rad52 is rescued by rad50 spo13, but not spo13, and is classified as late recombination gene. Growth defects of mgs1 rad18 double mutants are suppressed by overexpression of Rad52.; Deletion of this homologous recombination (HR) gene decreases psoralen-induced recombination and increases mutation frequencies.	RAD52
4932	YNL250W	Subunit of MRX complex, with Mre11p and Xrs2p, involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining	Null mutant is viable but defective for X-ray damage repair, sporulation, chromosome pairing, formation and processing of DS breaks, gene conversion and reciprocal recombination in non-rDNA, tripartite synaptonemal complexes and heteroduplex DNA. Exhibits blocked meiotic recombination and formation of synaptonemal complex at early stages. rad50-1 or null is rescued by spo13 and rescues rad52 spo13.	RAD50
4932	YNL271C	Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1	Null mutant is viable, bni1 bnr1 double deletion mutants are temperature sensitive and are deficient in bud emergence, exhibit a random distribution of cortical actin patches and often become multinucleate at the restrictive temperature; rho1 bni1 double mutants exhibit synthetic lethality	BNI1
4932	YNL298W	Cdc42p activated signal transducing kinase of the PAK (p21-activated kinase) family, involved in septin ring assembly and cytokinesis; directly phosphorylates septins Cdc3p and Cdc10p; other yeast PAK family members are Ste20p and Skm1p	Null mutant is viable, possesses a cytokinesis defect; cla4 cln1 cln2 strains are inviable; cla4 ste20 double deletion mutants cannot maintain septin rings at the bud neck and and cannot undergo cytokinesis	CLA4
4932	YOL012C	Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin	Null mutant is viable at 28C; high copy suppressor of histone H4 point mutant affecting nucleosome structure	HTZ1
4932	YOR026W	Kinetochore checkpoint WD40 repeat protein that localizes to kinetochores during prophase and metaphase, delays anaphase in the presence of unattached kinetochores; forms complexes with Mad1p-Bub1p and with Cdc20p, binds Mad2p and Mad3p		BUB3
4932	YPL055C	Protein of unknown function; null mutant forms abnormally large cells	Null: large cell size. Other phenotypes: synthetic lethal with swi4	LGE1
4932	YPR135W	Chromatin-associated protein, required for sister chromatid cohesion; interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesion	Null mutant is viable but shows increase in the rate of mitotic chromosome loss, increased mitotic recombination, shift toward cells with G2 DNA content, and large budded cells with the nucleus in the bud neck; shows synthetic interactions with rad52, pol1, rad9, and esr1	CTF4
4932	YPR141C	Minus-end-directed microtubule motor that functions in mitosis and meiosis, localizes to the spindle pole body and localization is dependent on functional Cik1p, required for nuclear fusion during mating; potential Cdc28p substrate	Null mutant is viable. Mutations in KAR3 are semidominant and cause pleiotropic effects affecting both mitosis and meiosis. kar3 mutations prevent karyogamy (nuclear fusion).	KAR3