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SONAR Targetspace for CYCLOSPORINEZ-score WebGraph NB WebGraph
Targetspace hs 172 101
Targetspace hs pval0.0503144654088050.13092550790068
XgmmL File for compound download download
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Dynamic Data Scan For Putative Targets (genetic,physical,all)
Prediction Returned Rows:40
Sym Orf⇑ Description Function No All Z_score hyperg
FLC2 YAL053W Putative protein of unknown function; green fluorescent protein (GFP)-fusion pro...   3 7   0.0315
FUS3 YBL016W Mitogen-activated protein kinase involved in mating pheromone response; activate... CDC28/cdc2 related protein kinase 3 129   0.0002
FTH1 YBR207W Putative high affinity iron transporter involved in transport of intravacuolar s...   3 10   0
TRS20 YBR254C One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-...   4 23   0
VAM6 YDL077C Vacuolar protein that plays a critical role in the tethering steps of vacuolar m...   7 39   0.0834
VPS54 YDR027C Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps5...   5 22   0
RGP1 YDR137W Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleot...   6 10 -9.4689 0
VPS52 YDR484W Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps5...   6 12   0
GDI1 YER136W GDP dissociation inhibitor, regulates vesicle traffic in secretory pathways by r... GDP dissociation inhibitor 14 25   0
PMR1 YGL167C High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into ... Ca2+ ATPase 4 22 1.3874 0.0777
YIP4 YGL198W Protein that interacts with Rab GTPases; computational analysis of large-scale p...   7 26   0
MDR1 YGR100W Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p, Ypt31... GTPase activating protein (GAP) for Ypt6 12 13   0
COG2 YGR120C Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog...   7 45   NAN
YIP1 YGR172C Integral membrane protein required for the biogenesis of ER-derived COPII transp...   7 28   0.0001
PHB2 YGR231C Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mit... mammalian BAP37 and S. cerevisiae Phb1p homolog|prohibitin homolog 4 21   0.0001
ZUO1 YGR285C Cytosolic ribosome-associated chaperone that acts, together with Ssz1p and the S... zuotin, Z-DNA binding protein (putative) 6 50   0
SSZ1 YHR064C Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) to form a ribosome-asso... HSP70 family 4 85   0
CBR1 YIL043C Microsomal cytochrome b reductase, not essential for viability; also detected in... cytochrome b reductase 3 27   0.1524
VPS53 YJL029C Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps5... hydrophilic protein that is peripherally associated with the late Golgi and forms a stable complex with Vps52p and Vps54p 7 18   0.0001
GYP6 YJL044C GTPase-activating protein (GAP) for the yeast Rab family member, Ypt6p; involved... GTPase activating protein (GAP) for Ypt6 14 13   0
APL1 YJR005W Beta-adaptin, large subunit of the clathrin associated protein complex (AP-2); i... beta-adaptin|clathrin associated protein complex large subunit 4 16   0
SPC1 YJR010C-A Subunit of the signal peptidase complex (SPC), which cleaves the signal sequence...   3 36   0
MIR1 YJR077C Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; ...   3 29   0
SGM1 YJR134C Protein of unknown function, required for wild-type growth rate on galactose and...   6 8   0.0256
BET3 YKR068C Hydrophilic protein that acts in conjunction with SNARE proteins in targeting an... transport protein particle (TRAPP) component 4 34   0
RIC1 YLR039C Protein involved in retrograde transport to the cis-Golgi network; forms heterod...   9 14 -4.5173 0
YEF3 YLR249W Translational elongation factor, stimulates the binding of aminoacyl-tRNA (AA-tR... Translation elongation factor 3 (EF-3) 4 94   0
ACO1 YLR304C Aconitase, required for the tricarboxylic acid (TCA) cycle and also independentl... aconitase 6 28   0
VPS33 YLR396C ATP-binding protein that is a subunit of the homotypic vacuole fusion and vacuol...   7 35   0
ERV41 YML067C Protein localized to COPII-coated vesicles, forms a complex with Erv46p; involve...   4 15   0
ERO1 YML130C Glycoprotein required for oxidative protein folding in the endoplasmic reticulum   4 11   0.0001
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family, redundant in function and nearly iden... chaperonin 4 144   0.1769
RNA1 YMR235C GTPase activating protein (GAP) for Gsp1p, involved in nuclear transport GTPase activating protein (GAP) for Gsp1p 6 27   0
SSN8 YNL025C Cyclin-like component of the RNA polymerase II holoenzyme, involved in phosphory... C-type cyclin|associates with the Ssn3p cyclin-dependent kinase 3 50   0.0025
COG6 YNL041C Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cyt...   6 31   0
YIP3 YNL044W Protein localized to COPII vesicles, proposed to be involved in ER to Golgi tran...   15 43   NAN
YIF1 YNL263C Integral membrane protein required for the fusion of ER-derived COPII transport ...   6 39   0
MSB4 YOL112W GTPase-activating protein of the Ras superfamily that acts primarily on Sec4p, l...   6 11   0
MRS6 YOR370C Rab escort protein, forms a complex with the Ras-like small GTPase Ypt1p that is... rab geranylgeranyltransferase regulatory subunit 7 22   0
YOP1 YPR028W Membrane protein that interacts with Yip1p to mediate membrane traffic; overexpr...   7 17   0

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