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SONAR Targetspace for CYCLOSPORINEZ-score WebGraph NB WebGraph
Targetspace hs 172 101
Targetspace hs pval0.0503144654088050.13092550790068
XgmmL File for compound download download
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Dynamic Data Scan For Putative Targets (genetic,physical,all)
Prediction Returned Rows:36
Sym Orf Description Function No All Z_score⇑ hyperg
  YDR266C     9 36   0
  YGR071C     8 54   0.0364
  YIL039W     9 115   0
  YOR246C     9 92   0
ASM4 YDL088C Nuclear pore complex subunit, part of a subcomplex also containing Nup53p, Nup17... nuclear pore complex subunit 10 94   0
CMP2 YML057W Calcineurin A; one isoform (the other is CNA1) of the catalytic subunit of calci... calcineurin subunit A 10 46   0
COG2 YGR120C Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog...   11 94   NAN
DBR1 YKL149C RNA lariat debranching enzyme, involved in intron turnover; required for efficie... RNA lariat debranching enzyme 10 56   0
DCR2 YLR361C Putative phosphoesterase that functions as a dosage-dependent positive regulator...   9 77   0
DOT5 YIL010W Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase dur...   8 25   0
EDC1 YGL222C RNA-binding protein, activates mRNA decapping directly by binding to the mRNA su...   12 28   0
EGD1 YPL037C Subunit beta1 of the nascent polypeptide-associated complex (NAC) involved in pr... pol II transcribed genes regulator 12 80   0
FAR11 YNL127W Protein involved in G1 cell cycle arrest in response to pheromone, in a pathway ...   9 104   0.012
GDI1 YER136W GDP dissociation inhibitor, regulates vesicle traffic in secretory pathways by r... GDP dissociation inhibitor 14 37   0
GYP6 YJL044C GTPase-activating protein (GAP) for the yeast Rab family member, Ypt6p; involved... GTPase activating protein (GAP) for Ypt6 12 107   0
IRS4 YKR019C Protein involved in regulation of phosphatidylinositol 4,5-bisphosphate concentr...   12 112   0.0002
MDR1 YGR100W Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p, Ypt31... GTPase activating protein (GAP) for Ypt6 12 34   0
MET6 YER091C Cobalamin-independent methionine synthase, involved in amino acid biosynthesis; ... 5-methyltetrahydropteroyl triglutamate homocysteine methyltransferase|N5-methyltetrahydrofolate homocysteine methyltransferase|vitamin B12-(cobalamin)-independent methionine synthase 14 88   0
MRL1 YPR079W Membrane protein with similarity to mammalian mannose-6-phosphate receptors, pos...   9 55   0.0846
MUD1 YBR119W U1 snRNP A protein, homolog of human U1-A; involved in nuclear mRNA splicing U1 snRNP A protein 11 109   0
MVP1 YMR004W Protein required for sorting proteins to the vacuole; overproduction of Mvp1p su...   10 89   0
QCR6 YFR033C Subunit 6 of the ubiquinol cytochrome-c reductase complex, which is a component ... ubiquinol cytochrome C oxidoreductase subunit 6 (17 kDa) 13 60   0
RAV2 YDR202C Subunit of RAVE (Rav1p, Rav2p, Skp1p), a complex that associates with the V1 dom...   10 103   0.0724
RNH70 YGR276C 3- exoribonuclease, required for 5S and tRNA-Arg3 maturation ribonuclease H 12 79   0
SAP185 YJL098W Protein that forms a complex with the Sit4p protein phosphatase and is required ...   11 126   0
SDS22 YKL193C Conserved nuclear regulatory subunit of Glc7p type 1 protein serine-threonine ph... Glc7p regulatory subunit 10 95   0
SEC21 YNL287W Gamma subunit of coatomer, a heptameric protein complex that together with Arf1p... PEST sequence-containing protein|non-clathrin coat protein 8 67   0
SNX4 YJL036W Sorting nexin, involved in the retrieval of late-Golgi SNAREs from the post-Golg...   10 100   0
STV1 YMR054W Subunit of vacuolar-ATPase V0 domain, one of two isoforms (Stv1p and Vph1p); Stv... 110 kDa subunit; not in vacuole membrane|vacuolar H-ATPase 11 71   0
SYG1 YIL047C Plasma membrane protein of unknown function; truncation and overexpression suppr... plasma membrane protein 10 46   0
UPF3 YGR072W Component of the nonsense-mediated mRNA decay (NMD) pathway, along with Nam7p an...   9 134   0.1295
USO1 YDL058W Essential protein involved in intracellular protein transport, coiled-coil prote... integrin analogue gene 10 79   0
VPS30 YPL120W Protein that forms a membrane-associated complex with Apg14p that is essential f...   12 109   0.0014
YIP1 YGR172C Integral membrane protein required for the biogenesis of ER-derived COPII transp...   14 48   0
YPT1 YFL038C Ras-like small GTPase, involved in the ER-to-Golgi step of the secretory pathway... GTP-binding protein|ras homolog|similar to mammalian Rab1A protein 10 91   0.0143
VPH1 YOR270C Subunit of vacuolar-ATPase V0 domain, one of two isoforms (Vph1p and Stv1p); Vph... V0 sector subunit|essential for vacuolar acidification and vacuolar H-ATPase activity|vacuolar ATPase V0 domain subunit a (100 kDa)|vacuolar H-ATPase 11 123 -1.9054 0.0018

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