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SONAR Targetspace for alpha-MANGOSTINZ-score WebGraph NB WebGraph
Targetspace hs 211 257
Targetspace hs pval0.204326923076920.29457364341085
XgmmL File for compound download download
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Dynamic Data Scan For Putative Targets (genetic,physical,all)
Prediction Returned Rows:37
Sym Orf Description Function No All Z_score hyperg
SMI1 YGR229C Protein involved in the regulation of cell wall synthesis; proposed to be involv... 57 kDa nuclear protein 26 145 -16.6491 NAN
FKS1 YLR342W Catalytic subunit of 1,3-beta-D-glucan synthase, functionally redundant with alt... 1,3-beta-D-glucan synthase 20 126 -5.1150 0
MYO2 YOR326W One of two type V myosins, involved in polarized distribution of mitochondria; r... class V myosin 20 104   0
CNB1 YKL190W Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulate... calcineurin regulatory B subunit|type 2B protein phosphatase 19 81 -21.1770 0
GAS1 YMR307W Beta-1.3-glucanosyltransferase, required for cell wall assembly; localizes to th... cell surface glycoprotein 115-120 kDa 18 111 -5.3102 0
PTC1 YDL006W Type 2C protein phosphatase (PP2C); inactivates the osmosensing MAPK cascade by ...   15 64   0.0991
TPM1 YNL079C Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments... tropomyosin I 15 46   0
MID2 YLR332W O-glycosylated plasma membrane protein that acts as a sensor for cell wall integ...   15 46   0.0369
FPS1 YLL043W Plasma membrane glycerol channel, member of the major intrinsic protein (MIP) fa... glycerol channel protein 15 28   0.0286
SPA2 YLL021W Component of the polarisome, which functions in actin cytoskeletal organization ...   14 54   0
CHS5 YLR330W Protein of unknown function, involved in chitin biosynthesis by regulating Chs3p...   14 107 -22.6232 0
CCW12 YLR110C Cell wall protein, mutants are defective in mating and agglutination, expression... cell wall mannoprotein 13 115   0
KRE1 YNL322C Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer t...   12 119 -7.9235 0
PPZ2 YDR436W Serine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation...   12 10   0.081
RVS167 YDR388W Actin-associated protein, subunit of a complex (Rvs161p-Rvs167p) involved in reg... cytoskeletal protein (putative) 12 108 -9.3147 0
SIW14 YNL032W Tyrosine phosphatase that plays a role in actin filament organization and endocy... tyrosine phosphatase 12 16   0
PCL2 YDL127W G1 cyclin, associates with Pho85p cyclin-dependent kinase (Cdk) to contribute to... G1 cyclin 11 19   0.0001
PPZ1 YML016C Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation...   11 31 -16.4741 0.0839
KRE11 YGR166W Protein involved in biosynthesis of cell wall beta-glucans; subunit of the TRAPP...   11 62   0
RIM101 YHL027W Transcriptional repressor involved in the response to pH; required for alkaline ...   10 65   0.1272
PTC4 YBR125C Cytoplasmic type 2C protein phosphatase; identified as a high-copy number suppre... type 2C protein phosphatase 10 4   0.1342
RPI1 YIL119C Putative transcriptional regulator; overexpression suppresses the heat shock sen... ras inhibitor 10 9   0.0011
  YKL037W     10 12   0.0015
  YKL161C     10 5   0.1116
ROT1 YMR200W Protein that may be involved in cell wall function; mutations in rot1 cause cell... membrane protein (putative) 10 27   0
ROM2 YLR371W GDP/GTP exchange protein (GEP) for Rho1p and Rho2p; mutations are synthetically ...   10 71 -28.2946 0.14
OPI3 YJR073C Phospholipid methyltransferase (methylene-fatty-acyl-phospholipid synthase), cat... unsaturated phospholipid N-methyltransferase 10 126   NAN
NBP2 YDR162C Protein involved in the HOG (high osmolarity glycerol) pathway, negatively regul...   10 93 -11.2946 0.0321
RUD3 YOR216C Golgi matrix protein involved in the structural organization of the cis-Golgi; i...   9 100   0
IKI3 YLR384C Subunit of RNA polymerase II elongator histone acetyltransferase complex, involv...   9 80 -0.8184 0
ARC40 YBR234C Essential subunit of the ARP2/3 complex, which is required for the motility and ...   9 44   NAN
TSC11 YER093C Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p), a membrane-associated co...   9 24   0
ERG11 YHR007C Lanosterol 14-alpha-demethylase, catalyzes the C-14 demethylation of lanosterol ... cytochrome P450 lanosterol 14a-demethylase 9 79   0.1268
BCK1 YJL095W Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinas... MEKK 9 89 -8.2270 0
URM1 YIL008W Ubiquitin-like protein with only weak sequence similarity to ubiquitin; depends ... ubiquitin-like protein 8 56   0
RHO1 YPR165W GTP-binding protein of the rho subfamily of Ras-like proteins, involved in estab... GTP-binding protein|rho subfamily 8 50   0.1504
MKK1 YOR231W Mitogen-activated kinase kinase involved in protein kinase C signaling pathway t... MAP kinase kinase (MEK) 8 26 -13.3797 0.1064

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