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SONAR Targetspace for ESTRONE HEMISUCCINATEZ-score WebGraph NB WebGraph
Targetspace hs 254 172
Targetspace hs pval0.0287474332648870.048117154811715
XgmmL File for compound download download
Stats file for targetspace download download
Targetspace Analysis download download
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Dynamic Data Scan For Putative Targets (genetic,physical,all)
Prediction Returned Rows:40
Sym Orf Description Function No All Z_score hyperg
GYP1 YOR070C Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in v... GTPase activating protein (GAP) 5 67   0
RER1 YCL001W Protein involved in retention of membrane proteins, including Sec12p, in the ER;...   5 73   0.0155
  YIL039W     5 65   0
RAV1 YJR033C Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of th...   5 30   0.1876
IMH1 YLR309C Protein involved in vesicular transport, mediates transport between an endosomal...   5 4   0.0002
MVP1 YMR004W Protein required for sorting proteins to the vacuole; overproduction of Mvp1p su...   5 16   0
GSG1 YDR108W Subunit of TRAPP (transport protein particle), a multi-subunit complex involved ...   5 97   0
PKR1 YMR123W Protein of unknown function; overproduction confers resistance to Pichia farinos...   5 32   0
ARL1 YBR164C Soluble GTPase with a role in regulation of membrane traffic; regulates potassiu... ADP-ribosylation factor-like protein 1 5 141   0
VPS17 YOR132W Subunit of the membrane-associated retromer complex essential for endosome-to-Go...   4 21   0.1825
SWA2 YDR320C Auxilin-like protein involved in vesicular transport; clathrin-binding protein r... auxilin-like protein 4 24   0
CDC50 YCR094W Endosomal protein that regulates cell polarity; similar to Ynr048wp and Lem3p   4 41   0
VPS30 YPL120W Protein that forms a membrane-associated complex with Apg14p that is essential f...   4 25   0.1995
TFP1 YDL185W Vacuolar ATPase V1 domain subunit A containing the catalytic nucleotide binding ... protein with three regions (ABC) that are spliced to yield the extein AC and the intein B; AC is a 69K vacuolar (H+)-ATPase, and B is a 50K site-specfic endonuclease named VDE (PI-SceI) that is homologous to HO. Cleavage is meiosis-specific and induces ge|site-specific endonuclease VDE (PI-SceI)|vacuolar ATPase V1 domain subunit A (69 kDa) 4 65 -2.0505 0.0185
RPL35A YDL191W Protein component of the large (60S) ribosomal subunit, identical to Rpl35Bp and... ribosomal protein L35A 4 13   0.1574
SRO9 YCL037C Cytoplasmic RNA-binding protein that associates with translating ribosomes; invo...   4 30   0.0179
COG6 YNL041C Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cyt...   3 57   0
RCE1 YMR274C Type II CAAX prenyl protease involved in the proteolysis and maturation of Ras a... protease 3 14   0.2087
  YMR010W     3 4   0
SKY1 YMR216C SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabo...   3 97   0
EMP70 YLR083C Protein whose 24kDa cleavage product is found in endosome-enriched membrane frac...   3 7   0.2319
MRL1 YPR079W Membrane protein with similarity to mammalian mannose-6-phosphate receptors, pos...   3 3   0.0757
PSD1 YNL169C Phosphatidylserine decarboxylase of the mitochondrial inner membrane, converts p... phosphatidylserine decarboxylase 3 45   0.0619
STV1 YMR054W Subunit of vacuolar-ATPase V0 domain, one of two isoforms (Stv1p and Vph1p); Stv... 110 kDa subunit; not in vacuole membrane|vacuolar H-ATPase 3 10   0
  YOR112W     3 6   0.1947
PPG1 YNR032W Putative serine/threonine protein phosphatase, required for glycogen accumulatio...   3 6   0.0595
OXR1 YPL196W Protein of unknown function required for normal levels of resistance to oxidativ...   3 2   0.0904
DSS4 YPR017C Nucleotide release factor functioning in the post-Golgi secretory pathway, requi... GDP dissociation factor for Sec4p 3 14   0.0751
SRO7 YPR032W Protein with roles in exocytosis and cation homeostasis; functions in docking an... yeast homolog of the Drosophila tumor suppressor, lethal giant larvae 3 34   0.0075
MAK3 YPR051W Catalytic subunit of N-terminal acetyltransferase of the NatC type; required for... N-acetyltransferase 3 20   0.0272
APL5 YPL195W Delta adaptin-like subunit of the clathrin associated protein complex (AP-3); fu... clathrin assembly complex AP-3 adaptin component delta-like subunit 3 9   0
PEP4 YPL154C Vacuolar aspartyl protease (proteinase A), required for the posttranslational pr... vacuolar proteinase A 3 17   0.1523
ESC8 YOL017W Protein involved in telomeric and mating-type locus silencing, interacts with Si...   3 10   0
SNC2 YOR327C Vesicle membrane receptor protein (v-SNARE) involved in the fusion between Golgi... vesicle-associated membrane protein (synaptobrevin) homolog 3 33   0.1966
EGD1 YPL037C Subunit beta1 of the nascent polypeptide-associated complex (NAC) involved in pr... pol II transcribed genes regulator 3 8   0.0112
  YPL105C     3 2   0
ENT4 YLL038C Protein of unknown function, contains an N-terminal epsin-like domain   3 4   0.208
SEC28 YIL076W Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein tr... epsilon-COP coatomer subunit 3 19   0
GMH1 YKR030W Golgi membrane protein of unknown function, interacts with Gea1p and Gea2p; requ...   3 5   0.0261
VPS41 YDR080W Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and ...   3 14   0.2218

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