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SONAR Targetspace for METHOTREXATE(+/-)Z-score WebGraph NB WebGraph
Targetspace hs 185 208
Targetspace hs pval0.0459290187891440.026639344262295
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Dynamic Data Scan For Putative Targets (genetic,physical,all)
Prediction Returned Rows:38
Sym Orf Description Function No All Z_score hyperg
SPA2 YLL021W Component of the polarisome, which functions in actin cytoskeletal organization ...   18 34   NAN
SLT2 YHR030C Serine/threonine MAP kinase involved in regulating the maintenance of cell wall ...   13 98 -13.0813 0
PTP2 YOR208W Phosphotyrosine-specific protein phosphatase involved in the inactivation of mit... tyrosine phosphatase 11 13   0
STE12 YHR084W Transcription factor that is activated by a MAP kinase signaling cascade, activa... transcription factor 10 39   0
BCK1 YJL095W Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinas... MEKK 10 143 -10.3368 0
MKK1 YOR231W Mitogen-activated kinase kinase involved in protein kinase C signaling pathway t... MAP kinase kinase (MEK) 10 38 -23.0707 0.1393
SMK1 YPR054W Middle sporulation-specific mitogen-activated protein kinase (MAPK) required for... MAP kinase 10 21   0
SWI6 YLR182W Transcription cofactor, forms complexes with DNA-binding proteins Swi4p and Mbp1... transcription factor 10 36   0.0391
ROM2 YLR371W GDP/GTP exchange protein (GEP) for Rho1p and Rho2p; mutations are synthetically ...   10 26 0.3411 0.14
MSG5 YNL053W Dual-specificity protein phosphatase required for maintenance of a low level of ... protein tyrosine phosphatase 10 16   0
DSK2 YMR276W Nuclear-enriched ubiquitin-like polyubiquitin-binding protein, required for spin... ubiquitin-like protein 9 37   0
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p), a transcriptional activa... transcription factor 9 24 -1.7240 0
PAF1 YBR279W RNA polymerase II-associated protein, defines a large complex that is biochemica...   9 51 -2.2529 0
MKK2 YPL140C Mitogen-activated kinase kinase involved in protein kinase C signaling pathway t... protein kinase 9 33   0
SMI1 YGR229C Protein involved in the regulation of cell wall synthesis; proposed to be involv... 57 kDa nuclear protein 9 25 -0.2687 NAN
DIA2 YOR080W Origin-binding F-box protein that forms an SCF ubiquitin ligase complex with Skp...   9 47 -4.4930 0.0654
RLM1 YPL089C MADS-box transcription factor, component of the protein kinase C-mediated MAP ki...   9 15   0.1182
PRS1 YKL181W 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, involved in nucleotide, his... ribose-phosphate pyrophosphokinase 8 25   0
PTP3 YER075C Phosphotyrosine-specific protein phosphatase involved in the inactivation of mit... tyrosine phosphatase 8 8   0
HRP1 YOL123W Subunit of cleavage factor I, a five-subunit complex required for the cleavage a... cleavage and polyadenylation factor CF I component involved in pre-mRNA 3--end processing 8 45   0
ARP2 YDL029W Essential component of the Arp2/3 complex, which is a highly conserved actin nuc... actin related protein 8 74   NAN
CDC45 YLR103C DNA replication initiation factor; recruited to MCM pre-RC complexes at replicat... chromosomal DNA replication initiation protein 7 35   0.0007
PMA1 YGL008C Plasma membrane H+-ATPase, pumps protons out of the cell; major regulator of cyt... plasma membrane H+-ATPase 7 50   0.0308
GND1 YHR183W 6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerat... 6-phosphogluconate dehydrogenase 7 29   0
TOK1 YJL093C Outward-rectifier potassium channel of the plasma membrane with two pore domains... outward-rectifier potassium channel 6 3   0.0006
CTF4 YPR135W Chromatin-associated protein, required for sister chromatid cohesion; interacts ... DNA polymerase alpha binding protein 6 38   0
NTA1 YJR062C Amidase, removes the amide group from N-terminal asparagine and glutamine residu... 52 kDa amidase specific for N-terminal asparagine and glutamine 6 12   0
CRM1 YGR218W Major karyopherin, involved in export of proteins, RNAs, and ribosomal subunits ... chromosome region maintenance protein 6 111   0
NPR1 YNL183C Protein kinase that stabilizes several plasma membrane amino acid transporters b... protein kinase homolog 6 39 -26.5957 0
LST8 YNL006W Protein required for the transport of amino acid permease Gap1p from the Golgi t...   6 38   0
RAD53 YPL153C Protein kinase, required for cell-cycle arrest in response to DNA damage; activa... protein kinase 6 132   0
SMP1 YBR182C Putative transcription factor involved in regulating the response to osmotic str...   6 11   0
NHA1 YLR138W Na+/H+ antiporter involved in sodium and potassium efflux through the plasma mem...   6 8   0
RPN6 YDL097C Essential, non-ATPase regulatory subunit of the 26S proteasome lid required for ... proteasome regulatory particle subunit 6 66   0.0058
SSK2 YNR031C MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; intera... MAP kinase kinase kinase|activator of Pbs2p 6 34   0
RPT3 YDR394W One of six ATPases of the 19S regulatory particle of the 26S proteasome involved...   6 99   0
SKO1 YNL167C Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family that for...   6 16   0
RCK2 YLR248W Protein kinase involved in the response to oxidative and osmotic stress; identif...   6 48   0

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