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SONAR Targetspace for METHOTREXATE(+/-)Z-score WebGraph NB WebGraph
Targetspace hs 185 208
Targetspace hs pval0.0459290187891440.026639344262295
XgmmL File for compound download download
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Dynamic Data Scan For Putative Targets (genetic,physical,all)
Prediction Returned Rows:31
Sym Orf Description Function No All Z_score hyperg
MKK2 YPL140C Mitogen-activated kinase kinase involved in protein kinase C signaling pathway t... protein kinase 16 66   0
PTP2 YOR208W Phosphotyrosine-specific protein phosphatase involved in the inactivation of mit... tyrosine phosphatase 15 51   0
STE12 YHR084W Transcription factor that is activated by a MAP kinase signaling cascade, activa... transcription factor 14 95   0
SDP1 YIL113W Stress-inducible dual-specificity MAP kinase phosphatase, negatively regulates S...   13 13   0
BNR1 YIL159W Formin, nucleates the formation of linear actin filaments, involved in cell proc...   13 82   0
  YKL161C     12 35   0.0526
SKO1 YNL167C Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family that for...   12 38   0
SPA2 YLL021W Component of the polarisome, which functions in actin cytoskeletal organization ...   11 103   0
SEC9 YGR009C t-SNARE protein important for fusion of secretory vesicles with the plasma membr... t-SNARE (putative) 10 128   0
RHO1 YPR165W GTP-binding protein of the rho subfamily of Ras-like proteins, involved in estab... GTP-binding protein|rho subfamily 10 91   0.0892
KAR1 YNL188W Essential protein involved in karyogamy during mating and in spindle pole body d...   10 23   0.0029
PMA2 YPL036W Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of ... plasma membrane ATPase 10 114   0
SMK1 YPR054W Middle sporulation-specific mitogen-activated protein kinase (MAPK) required for... MAP kinase 10 36   0
SGD1 YLR336C Essential nuclear protein with a possible role in the osmoregulatory glycerol re...   10 44   0
MSG5 YNL053W Dual-specificity protein phosphatase required for maintenance of a low level of ... protein tyrosine phosphatase 9 60   0
RHO5 YNL180C Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely... rho GTPase 9 14   0.008
RER2 YBR002C Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmi... cis-prenyltransferase 9 21   0
CHS6 YJL099W Protein of unknown function, involved in chitin biosynthesis by regulating Chs3p...   9 135   NAN
DNA2 YHR164C Essential tripartite DNA replication factor with single-stranded DNA-dependent A... DNA replication helicase 8 75   0.1171
GND1 YHR183W 6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerat... 6-phosphogluconate dehydrogenase 8 34   0
PRP6 YBR055C Splicing factor, component of the U4/U6-U5 snRNP complex RNA splicing factor 8 145   0
PIR1 YKL164C O-glycosylated protein required for cell wall stability; attached to the cell wa...   8 36   0
PRS1 YKL181W 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, involved in nucleotide, his... ribose-phosphate pyrophosphokinase 8 33   0
KIC1 YHR102W Protein kinase of the PAK/Ste20 kinase family, required for cell integrity possi...   8 37   0
SIW14 YNL032W Tyrosine phosphatase that plays a role in actin filament organization and endocy... tyrosine phosphatase 8 113   0
BEM3 YPL115C Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton o... rho GTPase activating protein (GAP) 8 84   0
  YOL019W     8 18   0
  YKL037W     8 16   0.0139
GSH1 YJL101C Gamma glutamylcysteine synthetase, catalyzes the first step in the gamma-glutamy... gamma-glutamylcysteine synthetase 8 150   0
SEC5 YDR166C Essential 107kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec... exocyst complex component 8 59   0
CDC15 YAR019C Protein kinase of the Mitotic Exit Network that is localized to the spindle pole... protein kinase domain 7 113   0.0377

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