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SONAR Targetspace for METHOTREXATE(+/-)Z-score WebGraph NB WebGraph
Targetspace hs 185 208
Targetspace hs pval0.0459290187891440.026639344262295
XgmmL File for compound download download
Stats file for targetspace download download
Targetspace Analysis download download
Dataset submitted download download

Dynamic Data Scan For Putative Targets (genetic,physical,all)
Prediction Returned Rows:38
Sym Orf Description Function No All Z_score hyperg
CCW12 YLR110C Cell wall protein, mutants are defective in mating and agglutination, expression... cell wall mannoprotein 12 115   0.0001
ERD1 YDR414C Predicted membrane protein required for the retention of lumenal endoplasmic ret...   11 83   0
ROT2 YBR229C Glucosidase II catalytic subunit required for normal cell wall synthesis; mutati... glucosidase II 11 92 -0.6036 0.0852
KAR1 YNL188W Essential protein involved in karyogamy during mating and in spindle pole body d...   10 16   0.0029
  YKL161C     10 5   0.1116
SIW14 YNL032W Tyrosine phosphatase that plays a role in actin filament organization and endocy... tyrosine phosphatase 10 16   0
TPM1 YNL079C Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments... tropomyosin I 10 46   0
RPI1 YIL119C Putative transcriptional regulator; overexpression suppresses the heat shock sen... ras inhibitor 10 9   0.0011
TCO89 YPL180W Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p), a complex that regulates g...   10 16   0
CWH41 YGL027C Processing alpha glucosidase I, ER type II integral membrane N-glycoprotein invo... glucosidase I 10 62   0.106
ALG6 YOR002W Glucosyltransferase, involved in transfer of oligosaccharides from dolichyl pyro... glucosyltransferase 10 78   0.133
RHO1 YPR165W GTP-binding protein of the rho subfamily of Ras-like proteins, involved in estab... GTP-binding protein|rho subfamily 9 50   0.1229
YUR1 YJL139C Mannosyltransferase of the KTR1 family, involved in protein N-glycosylation; loc... mannosyltransferase 9 29   0.0043
PPZ1 YML016C Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation...   9 31 0.2974 0.1429
RER2 YBR002C Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmi... cis-prenyltransferase 9 10   0
KRE11 YGR166W Protein involved in biosynthesis of cell wall beta-glucans; subunit of the TRAPP...   9 62   0
SEC2 YNL272C Guanyl-nucleotide exchange factor for the small G-protein Sec4p, located on cyto... GDP/GTP exchange factor 9 63   0
RRD2 YPL152W Activator of the phosphotyrosyl phosphatase activity of PP2A; regulates G1 phase...   8 15   0
PCL1 YNL289W Pho85 cyclin of the Pcl1,2-like subfamily, involved in entry into the mitotic ce... G1 cyclin|associates with PHO85 8 25   0.1527
PPZ2 YDR436W Serine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation...   8 10   0.1437
MSG5 YNL053W Dual-specificity protein phosphatase required for maintenance of a low level of ... protein tyrosine phosphatase 8 14   0
FPS1 YLL043W Plasma membrane glycerol channel, member of the major intrinsic protein (MIP) fa... glycerol channel protein 8 28   0.0002
DNA2 YHR164C Essential tripartite DNA replication factor with single-stranded DNA-dependent A... DNA replication helicase 8 61   0.1171
SEC5 YDR166C Essential 107kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec... exocyst complex component 8 44   0
TOR2 YKL203C PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex tha...   8 32   0
PTP2 YOR208W Phosphotyrosine-specific protein phosphatase involved in the inactivation of mit... tyrosine phosphatase 8 28   0
RIM101 YHL027W Transcriptional repressor involved in the response to pH; required for alkaline ...   8 65   0.0842
  YKL037W     8 12   0.0139
RHO5 YNL180C Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely... rho GTPase 7 8   0.0465
RGD1 YBR260C GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in con... GTPase activating protein (GAP) (putative) 7 22   0.0003
TSC11 YER093C Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p), a membrane-associated co...   7 24   0.0002
SEC15 YGL233W Essential 113kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec... exocyst complex component 7 103   0
RRM3 YHR031C DNA helicase involved in rDNA replication and Ty1 transposition; structurally an... DNA helicase 7 93   0.0242
HUR1 YGL168W Protein required for hydroxyurea resistance; has possible roles in DNA replicati...   7 29   0.0343
MKK2 YPL140C Mitogen-activated kinase kinase involved in protein kinase C signaling pathway t... protein kinase 7 7   0
BNR1 YIL159W Formin, nucleates the formation of linear actin filaments, involved in cell proc...   7 40   0.0006
PKC1 YBL105C Protein serine/threonine kinase essential for cell wall remodeling during growth...   7 102   0.0491
ACK1 YDL203C Hypothetical protein a TRP/SEL-1 domain containing protein 6 11   0

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