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SONAR Targetspace for MEGESTROL ACETATEZ-score WebGraph NB WebGraph
Targetspace hs 118 90
Targetspace hs pval0.0938864628820960.23703703703704
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Dynamic Data Scan For Putative Targets (genetic,physical,all)
Prediction Returned Rows:39
Sym Orf Description Function No All Z_score hyperg
GYP6 YJL044C GTPase-activating protein (GAP) for the yeast Rab family member, Ypt6p; involved... GTPase activating protein (GAP) for Ypt6 6 13   0
GDI1 YER136W GDP dissociation inhibitor, regulates vesicle traffic in secretory pathways by r... GDP dissociation inhibitor 6 25   0
YIP3 YNL044W Protein localized to COPII vesicles, proposed to be involved in ER to Golgi tran...   6 43   NAN
RIC1 YLR039C Protein involved in retrograde transport to the cis-Golgi network; forms heterod...   5 14 -1.4815 0
MDR1 YGR100W Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p, Ypt31... GTPase activating protein (GAP) for Ypt6 4 13   0
VPS53 YJL029C Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps5... hydrophilic protein that is peripherally associated with the late Golgi and forms a stable complex with Vps52p and Vps54p 3 18   0.0632
YEF3 YLR249W Translational elongation factor, stimulates the binding of aminoacyl-tRNA (AA-tR... Translation elongation factor 3 (EF-3) 3 94   0
YIP1 YGR172C Integral membrane protein required for the biogenesis of ER-derived COPII transp...   3 28   0.0657
MSB3 YNL293W GTPase-activating protein for Sec4p and several other Rab GTPases, regulates exo... GTPase activating protein (GAP) for Ypt6 3 27   0
  YCR079W     3 26   0
ERP2 YAL007C Protein that forms a heterotrimeric complex with Erp1p, Emp24p, and Erv25p; memb... p24 protein involved in membrane trafficking 3 32   0
COG2 YGR120C Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog...   3 45   0
MSB4 YOL112W GTPase-activating protein of the Ras superfamily that acts primarily on Sec4p, l...   3 11   0
VPS33 YLR396C ATP-binding protein that is a subunit of the homotypic vacuole fusion and vacuol...   3 35   0.0004
SGM1 YJR134C Protein of unknown function, required for wild-type growth rate on galactose and...   3 8   0.2273
YIP4 YGL198W Protein that interacts with Rab GTPases; computational analysis of large-scale p...   3 26   0
VAM6 YDL077C Vacuolar protein that plays a critical role in the tethering steps of vacuolar m...   3 39   0.1801
YOP1 YPR028W Membrane protein that interacts with Yip1p to mediate membrane traffic; overexpr...   3 17   0
ACO1 YLR304C Aconitase, required for the tricarboxylic acid (TCA) cycle and also independentl... aconitase 3 28   0
COG6 YNL041C Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cyt...   3 31   0
MRS6 YOR370C Rab escort protein, forms a complex with the Ras-like small GTPase Ypt1p that is... rab geranylgeranyltransferase regulatory subunit 3 22   0.0025
  YDR306C     2 13   0
BUD31 YCR063W Protein involved in bud-site selection; diploid mutants display a random budding...   2 41   0
FTH1 YBR207W Putative high affinity iron transporter involved in transport of intravacuolar s...   2 10   0
PRP6 YBR055C Splicing factor, component of the U4/U6-U5 snRNP complex RNA splicing factor 2 112   0
CIT2 YCR005C Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloaceta... citrate synthase 2 9   0
FUS3 YBL016W Mitogen-activated protein kinase involved in mating pheromone response; activate... CDC28/cdc2 related protein kinase 2 129   0.0063
KIN3 YAR018C Nonessential protein kinase with unknown cellular role protein kinase 2 25   0
FLC2 YAL053W Putative protein of unknown function; green fluorescent protein (GFP)-fusion pro...   2 7   0.1326
RGA2 YDR379W GTPase-activating protein for the polarity-establishment protein Cdc42p; implica... Rho-GTPase Activating Protein 2 25   0.0285
SPO7 YAL009W Integral nuclear/ER membrane protein of unknown function, required for normal nu...   2 8   0
CAR1 YPL111W Arginase, responsible for arginine degradation, expression responds to both indu... arginase 2 15   0
GCN5 YGR252W Histone acetyltransferase, acetylates lysine 14 on histone H3; catalytic subunit... histone acetyltransferase 2 119 -2.3708 0.0363
PDB1 YBR221C E1 beta subunit of the pyruvate dehydrogenase (PDH) complex, which is an evoluti... pyruvate dehydrogenase beta subunit (E1 beta) 2 31   0.1895
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family, redundant in function and nearly iden... chaperonin 2 144   0.2362
TRS20 YBR254C One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-...   2 23   0
CIT1 YNR001C Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloaceta... citrate synthase 2 4   0
RAD54 YGL163C DNA-dependent ATPase, stimulates strand exchange by modifying the topology of do...   2 10   0
RBG2 YGR173W Protein with similarity to mammalian developmentally regulated GTP-binding prote...   2 17   0

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