| Compound Information | SONAR Target prediction |
| Name: | MEPIVACAINE HYDROCHLORIDE |
| Unique Identifier: | SPE01504148 |
| MolClass: | Checkout models in ver1.5 and ver1.0 |
| Molecular Formula: | |
| Molecular Weight: | 259.626 g/mol |
| X log p: | 6.073 (online calculus) |
| Lipinksi Failures | 1 |
| TPSA | 20.31 |
| Hydrogen Bond Donor Count: | 0 |
| Hydrogen Bond Acceptors Count: | 3 |
| Rotatable Bond Count: | 3 |
| Canonical Smiles: | Cl.CN1CCCCC1C(=O)Nc1c(C)cccc1C |
| Source: | synthetic |
| Reference: | Mol Pharmacol 54: 162 (1998) |
| Therapeutics: | anesthetic (local) |
| Generic_name: | Mepivacaine |
| Chemical_iupac_name: | N-(2,6-dimethylphenyl)-1-methyl-piperidine-2-carboxamide |
| Drug_type: | Approved Drug |
| Pharmgkb_id: | PA450375 |
| Kegg_compound_id: | C07528 |
| Drugbank_id: | APRD01094 |
| Melting_point: | 150.5 oC |
| H2o_solubility: | Soluble (7000 mg/L) |
| Logp: | 2.674 |
| Isoelectric_point: | 7.7 |
| Cas_registry_number: | 96-88-8 |
| Mass_spectrum: | http://webbook.nist.gov/cgi/cbook.cgi?Spec=C96888&Index=0&Type=Mass&Large=on |
| Drug_category: | Anesthetics, Local; ATC:N01BB03 |
| Indication: | For production of local or regional analgesia and anesthesia by local infiltration, peripheral nerve block techniques, and central neural techniques including epidural and caudal blocks. |
| Pharmacology: | Mepivicaine is a local anesthetic of the amide type. Mepivicaine as a reasonably rapid onset and medium duration and is known by the proprietary names as Carbocaine and Polocaine. Mepivicaine is used in local infiltration and regional anesthesia. Systemic absorption of local anesthetics produces effects on the cardiovascular and central nervous systems. At blood concentrations achieved with normal therapeutic doses, changes in cardiac conduction, excitability, refractoriness, contractility, and peripheral vascular resistance are minimal. |
| Mechanism_of_action: | Local anesthetics block the generation and the conduction of nerve impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse, and by reducing the rate of rise of the action potential. In general, the progression of anesthesia is related to the diameter, myelination, and conduction velocity of affected nerve fibers. Clinically, the order of loss of nerve function is as follows: pain, temperature, touch, proprioception, and skeletal muscle tone. |
| Organisms_affected: | Humans and other mammals |
| Found: 205 nonactive as graph: single | with analogs | 1 2 3 4 5 6 7 8 9 10 Next >> [205] |
| Species: | 4932 |
| Condition: | BCK1 |
| Replicates: | 2 |
| Raw OD Value: r im | 0.8940±0.0280721 |
| Normalized OD Score: sc h | 1.0035±0.00475297 |
| Z-Score: | 0.4576±0.100974 |
| p-Value: | 0.648068 |
| Z-Factor: | -2.05758 |
| Fitness Defect: | 0.4338 |
| Bioactivity Statement: | Nonactive |
| ps |
| DBLink | Rows returned: 8 | 1 2 Next >> |
| 4062 | N-(2,6-dimethylphenyl)-1-methyl-piperidine-2-carboxamide |
| 66070 | N-(2,6-dimethylphenyl)-1-methyl-piperidine-2-carboxamide hydrochloride |
| 517315 | N-(2,6-dimethylphenyl)-1-methyl-3,4,5,6-tetrahydro-2H-pyridine-2-carboxamide chloride |
| 657372 | N-(2,6-dimethylphenyl)-1-methyl-piperidine-2-carboxamide; hydrogen(+1) cation; chloride |
| 3032799 | (2S)-N-(2,6-dimethylphenyl)-1-methyl-piperidine-2-carboxamide |
| 6918903 | (2R)-N-(2,6-dimethylphenyl)-1-methyl-3,4,5,6-tetrahydro-2H-pyridine-2-carboxamide |
| internal high similarity DBLink | Rows returned: 2 |
| AW 00661 | 0.9111 |
| SPE01503818 | 0.9890 |
| active | Cluster 16932 | Additional Members: 4 | Rows returned: 0 |
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