Home | Screening data | Screen comparisons | Search for compounds | Structure search

Compound InformationSONAR Target prediction
Name:

10-HYDROXYCAMPTOTHECIN

Unique Identifier:SPE01504123
MolClass: Checkout models in ver1.5 and ver1.0
Molecular Formula:
Molecular Weight:348.224 g/mol
X log p:9.164  (online calculus)
Lipinksi Failures1
TPSA58.97
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptors Count:7
Rotatable Bond Count:1
Canonical Smiles:CCC1(O)C(=O)OCC2C(=O)N3Cc4cc5cc(O)ccc5nc4C3=CC=21
Class:alkaloid
Source:Camptotheca acuminata
Reference:J Med Chem 29:1553 (1986); J Nat Prod 53:186 (1990)
Therapeutics:antineoplastic

Found: 203 nonactive | as graph: single | with analogs [1] << Back 1 2 3 4 5 6 7 8 9 10  Next >> [203]
Species: 4932
Condition: ARX1
Replicates: 2
Raw OD Value: r im 0.6217±0.0284257
Normalized OD Score: sc h 0.9860±0.0261577
Z-Score: -0.7426±1.34823
p-Value: 0.4615
Z-Factor: -17.0012
Fitness Defect: 0.7733
Bioactivity Statement: Nonactive
Experimental Conditions
Library:Spectrum
Plate Number and Position:7|F6
Drug Concentration:50.00 nM
OD Absorbance:600 nm
Robot Temperature:25.20 Celcius
Date:2007-10-11 YYYY-MM-DD
Plate CH Control (+):0.040249999999999994±0.00220
Plate DMSO Control (-):0.6352500000000001±0.02646
Plate Z-Factor:0.8599
png
ps
pdf

DBLink | Rows returned: 2
97226
4330531

internal high similarity DBLink | Rows returned: 2
LOPAC 00814 0.9800
SPE01502232 0.9800

active | Cluster 1530 | Additional Members: 9 | Rows returned: 5
LAT002A02 0
LOPAC 00814 0
SPE01502232 0
Prest102 0
LAT003C09 0

Service provided by the Mike Tyers Laboratory