Home | Screening data | Screen comparisons | Search for compounds | Structure search

Compound InformationSONAR Target prediction
Name:

SIROLIMUS

Unique Identifier:SPE01504008
MolClass: Checkout models in ver1.5 and ver1.0
Molecular Formula:C51H79NO13
Molecular Weight:834.545 g/mol
X log p:  (online calculus)
Lipinksi Failures
TPSA
Hydrogen Bond Donor Count:
Hydrogen Bond Acceptors Count:
Rotatable Bond Count:
Canonical Smiles:COC1CC(CCC1O)CC(C)C1CC(=O)C(C)C=C(C)C(O)C(OC)C(=O)C(C)CC(C)C=CC=CC=C(C
)C(CC2CCC(C)C(O)(O2)C(=O)C(=O)N2CCCCC2C(=O)O1)OC
Source:Streptomyces hygroscopicus
Therapeutics:immunosuppressant, antineoplastic; rapamycin

Found: 104 active as graph: single | with analogs [1] << Back 11 12 13 14 15 16 17 18 19 20  Next >> [104]
Species: 4932
Condition: ATP4
Replicates: 2
Raw OD Value: r im 0.0441±0.00282843
Normalized OD Score: sc h 0.0674±0.00450251
Z-Score: -34.7799±2.11384
p-Value: 0
Z-Factor: 0.8944
Fitness Defect: INF
Bioactivity Statement: Toxic
Experimental Conditions
Library:SPECMTS3
Plate Number and Position:20|F2
Drug Concentration:50.00 nM
OD Absorbance:600 nm
Robot Temperature:24.30 Celcius
Date:2008-03-06 YYYY-MM-DD
Plate CH Control (+):0.04015±0.00120
Plate DMSO Control (-):0.633975±0.01795
Plate Z-Factor:0.9131
png
ps
pdf

DBLink | Rows returned: 0

internal high similarity DBLink | Rows returned: 0

active | Cluster 4292 | Additional Members: 3 | Rows returned: 1
SPE01503968 0.56

Service provided by the Mike Tyers Laboratory